Efficacy of previous Omicron infection and booster vaccination against BA.5 subvariants

It has been updated divalent booster shot Proven effective against COVID-19, especially severe disease progression. However, its previous protective efficacy has been largely unexplored. Omicron After infection, booster vaccination.

new studywas published yesterday JAMA network opensought to estimate the protective efficacy of booster vaccination against previous COVID-19 BA.1 or BA.2 infection and Omicron BA.5 variant.

A nationwide population-based study was conducted in South Korea and utilized an extracted nested case-control design of the risk set. Study patients and controls at risk were selected from the Korean His COVID-19 Vaccine Efficacy (K-COVE) dataset. Cohorts were matched by age, sex and place of residence.

During the period of BA.5 predominance (August 1-31, 2022), all study patients were positive for COVID-19. Cases and controls never infected with COVID-19 were proportionally compared with patients previously infected with BA.1 or BA.2.

Vaccine efficacy was estimated using a logistic regression model to adjust for covariates such as health status, vaccination status, and infection history. Vaccine efficacy against BA.5 and severe infections among previously uninfected patients, previously her BA.1 infected patients and previously her BA.2 infected patients compared.

A total of 3415980 cases and 3415980 controls were included in the study. His cohort was 53.9% female, with a mean age of 40.2 years hers. In people with no history of COVID-19, the vaccine efficacy of 4 doses (2 doses, 1 booster and 1 bivalent booster in the primary series) was estimated at 16.1% for him. Vaccine efficacy was 89.5% for him previously infected with BA.1 and 94.3% for him previously infected with BA.2.

The efficacy of the 4-dose vaccine against serious BA.5 infections was 90.9% in naïve patients, 93.9% in those with previous BA.1 infection, and 92.9% in those with previous BA.2 infection. %was.

It is not surprising that previous COVID-19 BA.1 or BA.2 infection is highly protective against Omicron BA.5 subvariant in combination with bivalent booster vaccination. As previous studies have shown, 4 doses of vaccination are much more effective than 2 doses, especially against severe COVID-19 infections.

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