Health
Innovative nanofluidic device detects single proteins at high natural concentrations
In the evolving world of precision medicine, the need for methods that can measure biomolecules with the highest precision and specificity is paramount. Recognizing this, Associate Professor Yan Xu and his international research team at the Graduate School of Engineering, Osaka Metropolitan University, have made significant strides in this direction. They have developed an innovative nanofluidic device that can stochastically capture single proteins and digitally detect them at high natural concentrations. This breakthrough may lay the foundation for the future of personalized disease prevention and treatment.
Precision medicine aims to tailor preventive and therapeutic strategies based on an individual’s genetic data, environmental factors, lifestyle and other determinants. This requires accurate measurement of biomolecules such as genes and proteins within single cells. However, until now, no tools have been able to process minute amounts, typically picoliters (10 picoliters), of the contents of a single cell simultaneously.−12 L) – quantification of biomolecules in a highly concentrated cellular environment.
The device, named Nanofluidic Aptamer Nanoarray (NANa for short), is a nanochannel-based chip designed for the digital assay of individual molecules in ultra-small samples equivalent to single cells. Using synthetic antibodies known as aptamers, NANa can stochastically capture and digitally detect single molecules of target proteins, even in highly concentrated samples. These aptamers that bind to specific molecules are densely arrayed within the nanochannels of the device.
In the future, we would like to explore the possibility of practical demonstration using actual cell samples, digitization of the obtained measurement data, and fusion of image recognition technology using AI and biological big data.
Humans are complex organisms made up of a huge number of cells. We hope that his NANa, which digitizes information about the number of biomolecules in individual cells, will act as a bridge between life science and informatics, paving the way for future precision medicine. “
Yang Shu, Associate Professor, Graduate School of Engineering, Osaka Metropolitan University
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Reference magazines:
Jan, J. other. (2023). Nanofluidic aptamer nanoarrays that enable stochastic capture of single proteins at normal concentrations. small. doi.org/10.1002/smll.202301013.
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