Health
Mitochondrial impairment but not peripheral inflammation predicts greater Gulf War illness severity
Golomb, B. A. Diplomats’ mystery illness and pulsed radiofrequency/microwave radiation. Neural Comput. 30, 1–104. https://doi.org/10.1162/neco_a_01133 (2018).
Golomb, B. A., Koslik, H. J. & Redd, A. J. Fluoroquinolone-induced serious, persistent, multisymptom adverse effects. BMJ Case Rep. https://doi.org/10.1136/bcr-2015-209821 (2015).
Davies, D. R., Ahmed, G. M. & Freer, T. Chronic organophosphate induced neuropsychiatric disorder (COPIND): Results of two postal questionnaire surveys. J Nutr. Environ. Med. 9, 123–134 (1999).
Binns, J. H. et al. Research Advisory Committee on Gulf War Veterans’ Illnesses: Scientific Progress in Understanding Gulf War Veterans’ Illnesses: Report and Recommendations 1–141 (2004).
Cherry, N. et al. Health and exposures of United Kingdom Gulf war veterans. Part II: The relation of health to exposure. Occup. Environ. Med. 58, 299–306 (2001).
Gray, G. C., Reed, R. J., Kaiser, K. S., Smith, T. C. & Gastanaga, V. M. Self-reported symptoms and medical conditions among 11,868 Gulf War-era veterans: the Seabee Health Study. Am. J. Epidemiol. 155, 1033–1044 (2002).
Steele, L. Prevalence and patterns of Gulf War illness in Kansas veterans: Association of symptoms with characteristics of person, place, and time of military service. Am. J. Epidemiol. 152, 992–1002 (2000).
Fukuda, K. et al. Chronic multisymptom illness affecting Air Force veterans of the Gulf War. J. Am. Med. Assoc. 280, 981–988 (1998).
Golomb, B. A. et al. Coenzyme Q10 benefits symptoms in Gulf War veterans: Results of a randomized double-blind study. Neural Comput. 26, 2594–2651. https://doi.org/10.1162/NECO_a_00659 (2014).
Cherry, N. et al. Health and exposures of United Kingdom Gulf war veterans. Part I: The pattern and extent of ill health. Occup. Environ. Med. 58, 291–298 (2001).
Kang, H. K., Mahan, C. M., Lee, K. Y., Magee, C. A. & Murphy, F. M. Illnesses among United States veterans of the Gulf War: A population-based survey of 30,000 veterans. J. Occup. Environ. Med. 42, 491–501 (2000).
Unwin, C. et al. Health of UK servicemen who served in Persian Gulf War. Lancet 353, 169–178 (1999).
McCauley, L. A., Lasarev, M., Sticker, D., Rischitelli, D. G. & Spencer, P. S. Illness experience of Gulf War veterans possibly exposed to chemical warfare agents. Am. J. Prev. Med. 23, 200–206 (2002).
Steele, L. et al. Brain-immune interactions as the basis of Gulf War illness: Clinical assessment and deployment profile of 1990–1991 Gulf War Veterans in the Gulf War Illness Consortium (GWIC) multisite case-control study. Brain Sci. 11, 1132. https://doi.org/10.3390/brainsci11091132 (2021).
Simmons, R., Maconochie, N. & Doyle, P. Self-reported ill health in male UK Gulf War veterans: A retrospective cohort study. BMC Public Health 4, 27 (2004).
Zundel, C. G. et al. Rates of chronic medical conditions in 1991 Gulf War veterans compared to the general population. Int. J. Environ. Res. Public Health 16, 949. https://doi.org/10.3390/ijerph16060949 (2019).
Berardocco, D. DoD, CIA release Khamisiyah modeling data. GulfNEWS 1, 3 (1997).
General Accounting Office. Gulf War illnesses: DOD’s conclusions about U.S. Troops’ exposure cannot be adequately supported. In: GAO report number GAO-04-159. http://www.gao.gov/htext/d04159.html (2004).
Schumm, W. R. et al. Self-reported changes in subjective health and anthrax vaccination as reported by over 900 Persian Gulf War era veterans. Psychol. Rep. 90, 639–653 (2002).
Golomb, B. A. Acetylcholinesterase inhibitors and Gulf War illnesses. Proc. Natl. Acad. Sci. USA 105, 4295–4300. https://doi.org/10.1073/pnas.0711986105 (2008).
Cecchine, G., Golomb, B. A., Hilborne, L. H., Spektor, D. M. & Anthony, R. A. A Review of the Scientific Literature as it Pertains to Gulf War Illnesses: Pesticides Vol. 8 (RAND, Santa Monica, 2000).
Fricker, R. D. et al. Pesticide Use During the Gulf War: A Survey of Gulf War Veterans (RAND, Santa Monica, 2000).
Department of Defense. Environmental exposure report. Pesticides. In: Final Report. http://www.gulflink.osd.mil/pest_final (2003).
Presidential Advisory Committee on Gulf War Veterans’ Illnesses. Presidential Advisory Committee on Gulf War Veterans’ Illnesses: Final Report. (U.S. Government Printing Office, 1996).
Committee on the Evaluation of the Department of Defense Clinical Evaluation Program Division of Health Promotion and Disease Prevention Institute of Medicine. Adequacy of the Comprehensive Clinical Evaluation Program: A Focused Assessment (National Academy Press, 1997).
Binns, J. H. et al. Gulf War illness and the health of Gulf War veterans. In: Scientific Findings and Recommendations 1–454 (U.S. Government Printing Office, 2008).
Steele, L., Lockridge, O., Gerkovich, M. M., Cook, M. R. & Sastre, A. Butyrylcholinesterase genotype and enzyme activity in relation to Gulf War illness: preliminary evidence of gene-exposure interaction from a case-control study of 1991 Gulf War veterans. Environ. Health 14, 4. https://doi.org/10.1186/1476-069X-14-4 (2015).
Butterick, T. A. et al. Gulf War illness-associated increases in blood levels of interleukin 6 and C-reactive protein: Biomarker evidence of inflammation. BMC Res. Notes 12, 816. https://doi.org/10.1186/s13104-019-4855-2 (2019).
Johnson, G. J., Slater, B. C., Leis, L. A., Rector, T. S. & Bach, R. R. Blood biomarkers of chronic inflammation in Gulf War illness. PLOS ONE 11, e0157855. https://doi.org/10.1371/journal.pone.0157855 (2016).
Locker, A. R. et al. Corticosterone primes the neuroinflammatory response to Gulf War illness-relevant organophosphates independently of acetylcholinesterase inhibition. J. Neurochem. 142, 444–455. https://doi.org/10.1111/jnc.14071 (2017).
James, L. M. et al. Human Leukocyte Antigen (HLA) and Gulf War Illness (GWI): HLA-DRB1*13:02 spares subcortical atrophy in Gulf War veterans. EBioMedicine 26, 126–131. https://doi.org/10.1016/j.ebiom.2017.11.005 (2017).
Alshelh, Z. et al. In-vivo imaging of neuroinflammation in veterans with Gulf War illness. Brain Behav. Immun. 87, 498–507. https://doi.org/10.1016/j.bbi.2020.01.020 (2020).
Golomb, B. A. Oxidative stress and mitochondrial injury in chronic multisymptom conditions: From Gulf War illness to autism spectrum disorder. Nat. Proc. https://doi.org/10.1038/npre.2012.6847.1 (2012).
Koslik, H. J., Hamilton, G. & Golomb, B. A. Mitochondrial dysfunction in Gulf War illness revealed by 31 phosphorus magnetic resonance spectroscopy: A case-control study. PLOS ONE 9, e92887 (2014).
Chen, Y. et al. Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War Illness. PLOS ONE 12, e0184832. https://doi.org/10.1371/journal.pone.0184832 (2017).
Nguyen, H. et al. Exposure to Gulf War illness-related agents leads to the development of chronic pain and fatigue. Life Sci. 283, 119867. https://doi.org/10.1016/j.lfs.2021.119867 (2021).
Abdullah, L. et al. Translational potential of long-term decreases in mitochondrial lipids in a mouse model of Gulf War illness. Toxicology 372, 22–33. https://doi.org/10.1016/j.tox.2016.10.012 (2016).
Shetty, G. A. et al. Chronic oxidative stress, mitochondrial dysfunction, Nrf2 activation and inflammation in the hippocampus accompany heightened systemic inflammation and oxidative stress in an animal model of Gulf War illness. Front. Mol. Neurosci. 10, 182. https://doi.org/10.3389/fnmol.2017.00182 (2017).
Zakirova, Z. et al. Complementary proteomic approaches reveal mitochondrial dysfunction, immune and inflammatory dysregulation in a mouse model of Gulf War Illness. Prot. Clin. Appl. 11, 1600190. https://doi.org/10.1002/prca.201600190 (2017).
Braga, M. et al. Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. Apoptosis 13, 822–832. https://doi.org/10.1007/s10495-008-0216-7 (2008).
Reutelingsperger, C. P. & van Heerde, W. L. Annexin V, the regulator of phosphatidylserine-catalyzed inflammation and coagulation during apoptosis. Cell. Mol. Life Sci. 53, 527–532 (1997).
Golomb, B. A. et al. Lower blood malondialdehyde is associated with past pesticide exposure: Findings in Gulf War illness and healthy controls. Military Med Res (2021).
Golomb, B. A. et al. A pilot study of bioenergetic marker relationships in Gulf War illness: Phosphocreatine recovery vs. Citric acid cycle intermediates. Int. J. Environ. Res. Public Health 18, 1635. https://doi.org/10.3390/ijerph18041635 (2021).
Golomb, B. A., Nguyen, E. & Dinkeloo, E. Radiation exposure predicts reported vaccine adverse effects in veterans with Gulf War illness. Int. J. Environ. Res. Public Health 17, 7136. https://doi.org/10.3390/ijerph17197136 (2020).
Ismail, K. et al. Chronic fatigue syndrome and related disorders in UK veterans of the Gulf War 1990–1991: Results from a two-phase cohort study. Psychol. Med. 38, 953–961 (2007).
Yan, J. et al. Induction of lipid metabolism dysfunction, oxidative stress and inflammation response by tris(1-chloro-2-propyl)phosphate in larval/adult zebrafish. Environ Int 160, 107081. https://doi.org/10.1016/j.envint.2022.107081 (2022).
Xiang, D. & Wang, Q. PXR-mediated organophorous flame retardant tricresyl phosphate effects on lipid homeostasis. Chemosphere 284, 131250. https://doi.org/10.1016/j.chemosphere.2021.131250 (2021).
Sullivan, K. et al. Neuropsychological functioning in military pesticide applicators from the Gulf War: Effects on information processing speed, attention and visual memory. Neurotoxicol. Teratol. 65, 1–13. https://doi.org/10.1016/j.ntt.2017.11.002 (2018).
Ojo, J. O. et al. Exposure to an organophosphate pesticide, individually or in combination with other Gulf War agents, impairs synaptic integrity and neuronal differentiation, and is accompanied by subtle microvascular injury in a mouse model of Gulf War agent exposure. Neuropathology 34, 109–127. https://doi.org/10.1111/neup.12061 (2014).
Phillips, K. F. & Deshpande, L. S. Repeated low-dose organophosphate DFP exposure leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness. Neurotoxicology 52, 127–133. https://doi.org/10.1016/j.neuro.2015.11.014 (2016).
Phillips, K. F. & Deshpande, L. S. Chronic neurological morbidities and elevated hippocampal calcium levels in a DFP-based rat model of Gulf War illness. Mil. Med. 183, 552–555. https://doi.org/10.1093/milmed/usx148 (2018).
Scremin, O. U. et al. Low-dose cholinesterase inhibitors do not induce delayed effects on cerebral blood flow and metabolism. Pharmacol. Biochem. Behav. 80, 529–540. https://doi.org/10.1016/j.pbb.2004.12.013 (2005).
Nutter, T. J., Johnson, R. D. & Cooper, B. Y. A delayed chronic pain like condition with decreased Kv channel activity in a rat model of Gulf War Illness pain syndrome. Neurotoxicology 51, 67–79. https://doi.org/10.1016/j.neuro.2015.09.010 (2015).
Repine, J. E. et al. Inhalation of two putative Gulf War toxins by mice. J. Environ. Sci. Health B 51, 366–373. https://doi.org/10.1080/03601234.2016.1142318 (2016).
Husain, K. & Somani, S. M. Persistent/delayed toxic effects of low-dose sarin and pyridostigmine under physical stress (exercise) in mice. Indian J. Physiol. Pharmacol. 48, 150–164 (2004).
O’Callaghan, J. P., Kelly, K. A., Locker, A. R., Miller, D. B. & Lasley, S. M. Corticosterone primes the neuroinflammatory response to DFP in mice: Potential animal model of Gulf War illness. J. Neurochem. 133, 708–721. https://doi.org/10.1111/jnc.13088 (2015).
Yan, Q. et al. High-resolution metabolomic assessment of pesticide exposure in central valley, California. Chem. Res. Toxicol. 34, 1337–1347. https://doi.org/10.1021/acs.chemrestox.0c00523 (2021).
Yao, H. et al. Fatty acid oxidation protects against hyperoxia-induced endothelial cell apoptosis and lung injury in neonatal mice. Am. J. Respir. Cell Mol. Biol. 60, 667–677. https://doi.org/10.1165/rcmb.2018-0335OC (2019).
Guo, X. et al. IL-13 alleviates cardiomyocyte apoptosis by improving fatty acid oxidation in mitochondria. Front. Cell. Dev. Biol. 9, 736603. https://doi.org/10.3389/fcell.2021.736603 (2021).
Sun, R. et al. l-Carnitine protects against 1,4-benzoquinone-induced apoptosis and DNA damage by suppressing oxidative stress and promoting fatty acid oxidation in K562 cells. Environ. Toxicol. 35, 1033–1042. https://doi.org/10.1002/tox.22939 (2020).
Sun, J. et al. Berberine protects against palmitate-induced apoptosis in tubular epithelial cells by promoting fatty acid oxidation. Med. Sci. Monit. 24, 1484–1492. https://doi.org/10.12659/msm.908927 (2018).
Yang, W. M. & Lee, W. CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation. Biochem. Biophys. Res. Commun. 452, 715–721. https://doi.org/10.1016/j.bbrc.2014.08.145 (2014).
Henique, C. et al. Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis. J. Biol. Chem. 285, 36818–36827. https://doi.org/10.1074/jbc.M110.170431 (2010).
Wan, J. et al. Activation of PPARdelta up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic beta-cells. Biochem. Biophys. Res. Commun. 391, 1567–1572. https://doi.org/10.1016/j.bbrc.2009.12.127 (2010).
Samudio, I. et al. Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J. Clin. Investig. 120, 142–156. https://doi.org/10.1172/jci38942 (2010).
Fehm, H. L., Kern, W. & Peters, A. The selfish brain: Competition for energy resources. Prog. Brain Res. 153, 129–140 (2006).
Tein, I. Lipid Storage Myopathies Due to Fatty Acid Oxidation Defects in Neuromuscular Disorders of Infancy, Childhood, and Adolescence 761–795 (Elsevier, 2015).
Tein, I. Metabolic myopathies. Semin. Pediatr. Neurol. 3, 59–98. https://doi.org/10.1016/s1071-9091(96)80038-6 (1996).
Wong, W. A signal to warm up to. Sci Signal. 9, ec190–ec190 (2016).
Mortensen, S. A. et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: A randomized double-blind trial. JACC Heart Fail 2, 641–649. https://doi.org/10.1016/j.jchf.2014.06.008 (2014).
Mortensen, A. L., Rosenfeldt, F. & Filipiak, K. J. Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial. Clin. Cardiol. 26, 147–156 (2019).
Singh, R. B. et al. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc. Drugs Ther. 12, 347–353 (1998).
Alehagen, U., Johansson, P., Bjornstedt, M., Rosen, A. & Dahlstrom, U. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int. J. Cardiol. 167, 1860–1866. https://doi.org/10.1016/j.ijcard.2012.04.156 (2013).
Alehagen, U., Aaseth, J., Alexander, J. & Johansson, P. Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly. PLOS ONE 13, e0193120. https://doi.org/10.1371/journal.pone.0193120 (2018).
Johnson, G. J., Leis, L. A., Slater, B. C. & Bach, R. R. Elevated platelet count, C-reactive protein and thromboxane analog-induced platelet aggregation in patients with Gulf War veterans’ illnesses: Evidence of a chronic inflammatory state?. Blood Coagul. Fibrinolysis 7, 736–741. https://doi.org/10.1097/MBC.0b013e328362627f (2013).
James, L. M., Engdahl, B. E., Johnson, R. A. & Georgopoulos, A. P. Gulf War illness and inflammation: Association of symptom severity with C-reactive protein. J. Neurol. Neuromed. 4, 15–19 (2019).
Proctor, S. P., Harley, R., Wolfe, J., Heeren, T. & White, R. F. Health-related quality of life in Persian Gulf War veterans. Mil Med 166, 510–519 (2001).
Doebbeling, B. N. et al. Is there a Persian Gulf War syndrome? Evidence from a large population-based survey of veterans and nondeployed controls. Am. J. Med. 108, 695–704 (2000).
Siciliano, G. et al. Functional diagnostics in mitochondrial diseases. Biosci. Rep. 27, 53–67. https://doi.org/10.1007/s10540-007-9037-0 (2007).
Tarnopolsky, M. A. & Raha, S. Mitochondrial myopathies: diagnosis, exercise intolerance, and treatment options. Med. Sci. Sports Exerc. 37, 2086–2093 (2005).
Tsujita, Y. et al. A surviving case of mitochondrial cardiomyopathy diagnosed from the symptoms of multiple organ dysfunction syndrome. Int. J. Cardiol. 128, e43-45. https://doi.org/10.1016/j.ijcard.2007.05.072 (2008).
De Flora, S. et al. DNA adducts and chronic degenerative disease. Pathogenetic relevance and implications in preventive medicine. Mutat. Res. 366, 197–238 (1996).
Sastre, J., Pallardo, F. V. & Vina, J. The role of mitochondrial oxidative stress in aging. Free Radic. Biol. Med. 35, 1–8 (2003).
De Vivo, D. C. & DiMauro, S. Mitochondrial defects of brain and muscle. Biol. Neonate 58(Suppl 1), 54–69 (1990).
Pinto, M. & Moraes, C. T. Mitochondrial genome changes and neurodegenerative diseases. Biochem. Biophys. Acta 1842, 1198–1207. https://doi.org/10.1016/j.bbadis.2013.11.012 (2014).
Gardner, A. & Boles, R. G. Symptoms of somatization as a rapid screening tool for mitochondrial dysfunction in depression. Biopsychosoc. Med. 2, 7 (2008).
Myhill, S., Booth, N. E. & McLaren-Howard, J. Chronic fatigue syndrome and mitochondrial dysfunction. Int. J. Clin. Exp. Med. 2, 1–16 (2009).
Kroenke, K., Koslowe, P. & Roy, M. Symptoms in 18,495 Persian Gulf War veterans. Latency of onset and lack of association with self-reported exposures. J. Occup. Environ. Med. 40, 520–528 (1998).
Crimmins, D. et al. Mitochondrial encephalomyopathy: Variable clinical expression within a single kindred. J. Neurol. Neurosurg. Psychiatry 56, 900–905 (1993).
Dimauro, S. & Davidzon, G. Mitochondrial DNA and disease. Ann. Med. 37, 222–232 (2005).
Wei, Y. H. Mitochondrial DNA mutations and oxidative damage in aging and diseases: an emerging paradigm of gerontology and medicine. Proc. Natl. Sci. Counc. Repub. China B 22, 55–67 (1998).
Vattemi, G. et al. Overexpression of TNF-alpha in mitochondrial diseases caused by mutations in mtDNA: Evidence for signaling through its receptors on mitochondria. Free Radic. Biol. Med. 63, 108–114. https://doi.org/10.1016/j.freeradbiomed.2013.04.025 (2013).
Rayhan, R. U. et al. Exercise challenge in Gulf War illness reveals two subgroups with altered brain structure and function. PLOS ONE 8, e63903 (2013).
Golomb, B. A. & Evans, M. A. Statin adverse effects: A review of the literature and evidence for a mitochondrial mechanism. Am. J. Cardiovasc. Drugs 8, 373–418 (2008).
Amin, A. & Hamza, A. A. Oxidative stress mediates drug-induced hepatotoxicity in rats: A possible role of DNA fragmentation. Toxicology 208, 367–375. https://doi.org/10.1016/j.tox.2004.11.039 (2005).
Das, G. C., Bacsi, A., Shrivastav, M., Hazra, T. K. & Boldogh, I. Enhanced gamma-glutamylcysteine synthetase activity decreases drug-induced oxidative stress levels and cytotoxicity. Mol Carcinog 45, 635–647. https://doi.org/10.1002/mc.20184 (2006).
Denicola, A. & Radi, R. Peroxynitrite and drug-dependent toxicity. Toxicology 208, 273–288 (2005).
Fosslien, E. Adverse effects of nonsteroidal anti-inflammatory drugs on the gastrointestinal system. Ann. Clin. Lab. Sci. 28, 67–81 (1998).
McMillian, M. et al. Drug-induced oxidative stress in rat liver from a toxicogenomics perspective. Toxicol. Appl. Pharmacol. 207, 171–178. https://doi.org/10.1016/j.taap.2005.02.031 (2005).
Shuhendler, A. J., Pu, K., Cui, L., Uetrecht, J. P. & Rao, J. Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing. Nat. Biotechnol. 32, 373–380. https://doi.org/10.1038/nbt.2838 (2014).
Tafazoli, S., Spehar, D. D. & O’Brien, P. J. Oxidative stress mediated idiosyncratic drug toxicity. Drug Metab. Rev. 37, 311–325 (2005).
Verma, P., Bhattacharya, S. N., Banerjee, B. D. & Khanna, N. Oxidative stress and leukocyte migration inhibition response in cutaneous adverse drug reactions. Indian J. Dermatol. Venereol. Leprol. 78, 664. https://doi.org/10.4103/0378-6323.100519 (2012).
Joshi, G. et al. Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: Insight into chemobrain. Free Radic. Res. 39, 1147–1154 (2005).
Kovacic, P. & Cooksy, A. L. Unifying mechanism for toxicity and addiction by abused drugs: electron transfer and reactive oxygen species. Med. Hypotheses 64, 357–366. https://doi.org/10.1016/j.mehy.2004.07.021 (2005).
Varga, Z. V., Ferdinandy, P., Liaudet, L. & Pacher, P. Drug-induced mitochondrial dysfunction and cardiotoxicity. Am. J. Physiol. Heart Circ. Physiol. 309, H1453-1467. https://doi.org/10.1152/ajpheart.00554.2015 (2015).
Bastianon, C., Zanoni, R., Miolo, G., Caffieri, S. & Reddi, E. Mitochondria and plasma membrane as targets of UVA-induced toxicity of neuroleptic drugs fluphenazine, perphenazine and thioridazine. Int. J. Biochem. Cell Biol. 37, 901–908 (2005).
Boelsterli, U. A. & Lim, P. L. Mitochondrial abnormalities: A link to idiosyncratic drug hepatotoxicity?. Toxicol. Appl. Pharmacol. 220, 92–107 (2007).
de Mendoza, C., Sanchez-Conde, M., Ribera, E., Domingo, P. & Soriano, V. Could mitochondrial DNA quantitation be a surrogate marker for drug mitochondrial toxicity?. AIDS Rev. 6, 169–180 (2004).
Finsterer, J. & Zarrouk-Mahjoub, S. Mitochondrial toxicity of cardiac drugs and its relevance to mitochondrial disorders. Expert Opin. Drug Metab. Toxicol. 11, 15–24. https://doi.org/10.1517/17425255.2015.973401 (2015).
Foli, A. et al. Direct analysis of mitochondrial toxicity of antiretroviral drugs. AIDS 15, 1687–1694 (2001).
Swartz, M. N. Mitochondrial toxicity–new adverse drug effects. N. Engl. J. Med. 333, 1146–1148 (1995).
Wallace, K. B. & Starkov, A. A. Mitochondrial targets of drug toxicity. Annu. Rev. Pharmacol. Toxicol. 40, 353–388 (2000).
Wallace, D. C., Brown, M. D., Melov, S., Graham, B. & Lott, M. Mitochondrial biology, degenerative diseases and aging. BioFactors 7, 187–190 (1998).
Wallace, D. C. Mitochondrial DNA in aging and disease. Sci. Am. 277, 40–47 (1997).
Wallace, D. C. Mitochondrial genetics: A paradigm for aging and degenerative diseases?. Science 256, 628–632 (1992).
Wallace, D. C. et al. Mitochondrial DNA mutations in human degenerative diseases and aging. Biochem. Biophys. Acta 1271, 141–151 (1995).
Melov, S., Schneider, J. A., Coskun, P. E., Bennett, D. A. & Wallace, D. C. Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA. Neurobiol. Aging 20, 565–571 (1999).
Wallace, D. C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine. Annu. Rev. Genet. 39, 359–407 (2005).
Ramezani, M., Sahraei, Z., Simani, L., Heydari, K. & Shahidi, F. Coenzyme Q10 supplementation in acute ischemic stroke: Is it beneficial in short-term administration?. Nutr. Neurosci. 23, 640–645. https://doi.org/10.1080/1028415x.2018.1541269 (2020).
Sun, F., Cui, J., Gavras, H. & Schwartz, F. A novel class of tests for the detection of mitochondrial DNA-mutation involvement in diseases. Am. J. Hum. Genet. 72, 1515–1526 (2003).
Rosenfeldt, F. L. et al. Coenzyme Q10 in the treatment of hypertension: A meta-analysis of the clinical trials. J. Hum. Hypertens. 21, 297–306 (2007).
Finsterer, J. Autism spectrum disorder: A mitochondrial disorder. Iran. J. Child Neurol. 15, 115–117. https://doi.org/10.22037/ijcn.v16i2.33066 (2021).
Wen, Y. & Yao, Y. The Mitochondria Connection in Autism Spectrum Disorders (ed A. M. Grabrucker) (Exon Publications Copyright: The Authors, 2021).
Barone, R. et al. Mitochondrial fatty acid β-oxidation and resveratrol effect in fibroblasts from patients with autism spectrum disorder. J. Pers. Med. 11, 510. https://doi.org/10.3390/jpm11060510 (2021).
Curran, L. K. et al. Behaviors associated with fever in children with autism spectrum disorders. Pediatrics 120, e1386-1392. https://doi.org/10.1542/peds.2007-0360 (2007).
Grzadzinski, R., Lord, C., Sanders, S. J., Werling, D. & Bal, V. H. Children with autism spectrum disorder who improve with fever: Insights from the Simons Simplex Collection. Autism Res. 11, 175–184. https://doi.org/10.1002/aur.1856 (2018).
Golomb, B. A. et al. Depressed prostaglandins and leukotrienes in veterans with Gulf War illness. J. Environ. Sci. Health B 54(8), 623–639. https://doi.org/10.1080/03601234.2019.1596001 (2019).
Naviaux, R. K. et al. Metabolic features of Gulf War illness. PLOS ONE 14, e0219531. https://doi.org/10.1371/journal.pone.0219531 (2019).
Tirodkar, T. S. & Voelkel-Johnson, C. Sphingolipids in apoptosis. Exp. Oncol. 34, 231–242 (2012).
Jansen, K. M. & Pavlath, G. K. Prostaglandin F2alpha promotes muscle cell survival and growth through upregulation of the inhibitor of apoptosis protein BRUCE. Cell Death Differ. 15, 1619–1628. https://doi.org/10.1038/cdd.2008.90 (2008).
Thompson, C. H., Kemp, G. J., Sanderson, A. L. & Radda, G. K. Skeletal muscle mitochondrial function studied by kinetic analysis of postexercise phosphocreatine resynthesis. J. Appl. Physiol. 78, 2131–2139 (1995).
Heaton, K. J. et al. Quantitative magnetic resonance brain imaging in US army veterans of the 1991 Gulf War potentially exposed to sarin and cyclosarin. Neurotoxicology 28, 761–769 (2007).
Hodgin, K. S. et al. A placebo-controlled, pseudo-randomized, crossover trial of botanical agents for Gulf War illness: Resveratrol (Polygonum cuspidatum), Luteolin, and Fisetin (Rhus succedanea). Int. J. Environ. Res. Public Health 18, 2483. https://doi.org/10.3390/ijerph18052483 (2021).
Donovan, E. K. et al. A placebo-controlled, pseudo-randomized, crossover trial of botanical agents for Gulf War illness: Curcumin (Curcuma longa), Boswellia (Boswellia serrata), and French maritime pine bark (Pinus pinaster). Int. J. Environ. Res. Public Health 18, 2468. https://doi.org/10.3390/ijerph18052468 (2021).
Zhao, D. et al. Curcumin improves adipocytes browning and mitochondrial function in 3T3-L1 cells and obese rodent model. R Soc Open Sci 8, 200974. https://doi.org/10.1098/rsos.200974 (2021).
Zhang, J. et al. Curcumin attenuates D-galactosamine/lipopolysaccharide-induced liver injury and mitochondrial dysfunction in mice. J. Nutr. 144, 1211–1218. https://doi.org/10.3945/jn.114.193573 (2014).
Lan, J. et al. Curcumin alleviates arsenic-induced injury in duck skeletal muscle via regulating the PINK1/Parkin pathway and protecting mitochondrial function. Toxicol Appl Pharmacol 434, 115820. https://doi.org/10.1016/j.taap.2021.115820 (2022).
Li, X. et al. Resveratrol protects renal damages induced by periodontitis via preventing mitochondrial dysfunction in rats. Oral Dis. https://doi.org/10.1111/odi.14148 (2022).
Hyatt, J. K., de Cabo, R. & Mattison, J. A. Resveratrol blunts mitochondrial loss in slow and mixed skeletal muscle phenotypes of non-human primates following a long-term high fat/sugar diet. J. Diet Suppl. https://doi.org/10.1080/19390211.2022.2039340 (2022).
Chen, L. L. et al. Resveratrol attenuates high-fat diet-induced insulin resistance by influencing skeletal muscle lipid transport and subsarcolemmal mitochondrial β-oxidation. Metabolism 60, 1598–1609. https://doi.org/10.1016/j.metabol.2011.04.002 (2011).
Niu, W., Wang, H., Wang, B., Mao, X. & Du, M. Resveratrol improves muscle regeneration in obese mice through enhancing mitochondrial biogenesis. J Nutr Biochem 98, 108804. https://doi.org/10.1016/j.jnutbio.2021.108804 (2021).
Cheng, K. et al. Effects of early resveratrol intervention on skeletal muscle mitochondrial function and redox status in neonatal piglets with or without intrauterine growth retardation. Oxid. Med. Cell Longev. 2020, 4858975. https://doi.org/10.1155/2020/4858975 (2020).
Wang, D. et al. Resveratrol improves muscle atrophy by modulating mitochondrial quality control in STZ-induced diabetic mice. Mol Nutr Food Res 62, e1700941. https://doi.org/10.1002/mnfr.201700941 (2018).
Zheng, J. et al. Resveratrol improves insulin resistance of catch-up growth by increasing mitochondrial complexes and antioxidant function in skeletal muscle. Metabolism 61, 954–965. https://doi.org/10.1016/j.metabol.2011.11.005 (2012).
Attaluri, S. et al. Oral nano-curcumin in a model of chronic Gulf War illness alleviates brain dysfunction with modulation of oxidative stress, mitochondrial function, neuroinflammation, neurogenesis, and gene expression. Aging Dis. 13, 583–613. https://doi.org/10.14336/ad.2021.0829 (2022).
Haines, D. D., Ottenweller, J. E., Dickens, B. F., Mahmoud, F. F. & Levine, P. H. Activity of paraoxonase/arylesterase and butyrylcholinesterase in peripheral blood of Gulf War era veterans with neurologic symptom complexes or post-traumatic stress disorder. J. Occup. Environ. Med. 59, 1000–1006. https://doi.org/10.1097/JOM.0000000000001129 (2017).
Khaiboullina, S. F. et al. Cytokine expression provides clues to the pathophysiology of Gulf War illness and myalgic encephalomyelitis. Cytokine 72, 1–8. https://doi.org/10.1016/j.cyto.2014.11.019 (2015).
Le, Y., Shen, H., Yang, Z., Lu, D. & Wang, C. Comprehensive analysis of organophosphorus flame retardant-induced mitochondrial abnormalities: Potential role in lipid accumulation. Environ Pollut 274, 116541. https://doi.org/10.1016/j.envpol.2021.116541 (2021).
Farkhondeh, T., Mehrpour, O., Forouzanfar, F., Roshanravan, B. & Samarghandian, S. Oxidative stress and mitochondrial dysfunction in organophosphate pesticide-induced neurotoxicity and its amelioration: A review. Environ. Sci. Pollut. Res. Int. 27, 24799–24814. https://doi.org/10.1007/s11356-020-09045-z (2020).
Leung, M. C. K. & Meyer, J. N. Mitochondria as a target of organophosphate and carbamate pesticides: Revisiting common mechanisms of action with new approach methodologies. Reprod. Toxicol. 89, 83–92. https://doi.org/10.1016/j.reprotox.2019.07.007 (2019).
U.S. Food and Drug Administration. FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects. In: FDA Drug Safety Communications July 26 (2016).
Bleecker, M. L. Carbon monoxide intoxication. Handb. Clin. Neurol. 131, 191–203. https://doi.org/10.1016/b978-0-444-62627-1.00024-x (2015).
Knobeloch, L. & Jackson, R. Recognition of chronic carbon monoxide poisoning. WMJ 98, 26–29 (1999).
Wright, J. Chronic and occult carbon monoxide poisoning: We don’t know what we’re missing. Emerg. Med. J. 19, 386–390. https://doi.org/10.1136/emj.19.5.386 (2002).
Díaz-Resendiz, K. J. G. et al. Loss of mitochondrial membrane potential (ΔΨ(m) ) in leucocytes as post-COVID-19 sequelae. J. Leukoc. Biol. https://doi.org/10.1002/jlb.3ma0322-279rrr (2022).
Stefano, G. B. et al. Editorial: The pathogenesis of long-term neuropsychiatric COVID-19 and the role of microglia, mitochondria, and persistent neuroinflammation: A hypothesis. Med. Sci. Monit. 27, e933015. https://doi.org/10.12659/msm.933015 (2021).
Pozzi, A. COVID-19 and mitochondrial non-coding RNAs: New insights from published data. Front. Physiol. 12, 805005. https://doi.org/10.3389/fphys.2021.805005 (2021).
National Academies of Sciences Engineering and Medicine. An Assessment of Illness in U.S. Government Employees and Their Families at Overseas Embassies (National Academies Press (US) Copyright 2020 by the National Academy of Sciences. All Rights Reserved, 2020).
Stewart, J. B. & Chinnery, P. F. The dynamics of mitochondrial DNA heteroplasmy: Implications for human health and disease. Nat. Rev. Genet. 16, 530–542. https://doi.org/10.1038/nrg3966 (2015).
Zaki, E. A. et al. Two common mitochondrial DNA polymorphisms are highly associated with migraine headache and cyclic vomiting syndrome. Cephalalgia 29, 719–728. https://doi.org/10.1111/j.1468-2982.2008.01793.x (2009).
Koillinen, H., Jaaskelainen, S. & Koski, K. Mitochondrial disorder underlying headache symptoms. Duodecim 125, 297–300 (2009).
Rosen, N. Headache and mitochondrial disorders. Headache 48, 733–734. https://doi.org/10.1111/j.1526-4610.2008.01118.x (2008).
Koga, Y. & Nataliya, P. Migraine headache and mitochondrial DNA abnormality. Nihon. Rinsho. 63, 1720–1726 (2005).
Wang, Q. et al. Mitochondrial DNA control region sequence variation in migraine headache and cyclic vomiting syndrome. Am. J. Med. Genet. A 131, 50–58. https://doi.org/10.1002/ajmg.a.30323 (2004).
Keevil, B. G., Nicholls, S. P. & Kilpatrick, E. S. Evaluation of a latex-enhanced immunoturbidimetric assay for measuring low concentrations of C-reactive protein. Ann. Clin. Biochem. 35(Pt 5), 671–673. https://doi.org/10.1177/000456329803500512 (1998).
Guralnik, J. M. et al. A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission. J. Gerontol. 49, M85–M94 (1994).
Golomb, B. A. & Koperski, S. Who becomes weak on statins? Effect modification exposed in a RCT by risk factor compounding. Circulation 127, AP072 (2013).
Shanely, R. A. et al. Human skeletal muscle biopsy procedures using the modified Bergström technique. J. Vis. Exp. https://doi.org/10.3791/51812 (2014).
Schöpf, B. et al. Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. FEBS J. 283, 2181–2196. https://doi.org/10.1111/febs.13733 (2016).
University of Virginia. Sign Test. http://www.fon.hum.uva.nl/Service/CGI-Inline/HTML/Statistics/Sign_Test.html. Access Date 8–28–2019 (2019).
White, H. A heteroskedasticity-consistent covariance matrix estimator and a direct test for heteroskedasticity. Econometrica 48, 817–838 (1980).
Rothman, K. J. No adjustments are needed for multiple comparisons. Epidemiology 1, 43–46 (1990).
Sources 2/ https://www.nature.com/articles/s41598-023-35896-w The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]