Study suggests drug infused with gold nanocrystals may improve Parkinson's disease

These tiny gold particles are cleverly designed to slip through the blood-brain barrier.

There is a glimmer of hope for patients with Parkinson's disease, multiple sclerosis, and other neurodegenerative diseases. Clinical trials of the drug CNM-Au8 have shown that it may slow the decline of neurons by boosting brain metabolism. The unique twist? Delivered daily as sprinkles containing gold nanoparticles.

This isn't your typical sprinkle-on treatment. These tiny gold particles are cleverly designed to slip through the blood-brain barrier, a major hurdle in treating brain diseases. Once inside, they act like microscopic power plants, enhancing energy production in neurons and potentially preventing degeneration.

Phase II trials suggest success, but researchers remain cautious. Further studies are underway to confirm safety and long-term efficacy. However, early results are exciting and provide a potential new weapon in the fight against these debilitating diseases.

The survey results are Nanobiotechnology JournalThe authors say this could ultimately help bring treatments to patients with these and other neurodegenerative diseases.

“We are cautiously optimistic that this strategy will prevent and even reverse some neurological disorders.” Peter Sugina saidM.D., who leads clinical trials in MS, is an assistant professor of neurology and a research associate at the Peter O'Donnell Jr. Brain Institute at UT Southwestern.

Dr. Sguigna and his colleagues at UTSW conducted two phase 2 clinical trials, REPAIR-MS and REPAIR-PD, in 11 patients with relapsing MS and 13 patients with Parkinson's disease. This study investigated the efficacy of CNM-Au8, an orally administered treatment developed by Clene Nanomedicine.

This treatment utilizes gold nanocrystals to increase the NAD+/NADH ratio to address the accelerated decline seen in neurodegenerative conditions.

The results suggest that the energy balance of brain cells may be improved, offering hope for slowing the progression of neurodegenerative diseases. This study aimed to highlight the importance of energy metabolism in neurodegenerative diseases and confirm the effect of CNM-Au8 on the NAD+/NADH ratio in human patients.

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