Immunotherapy Drug Offers Cure Without Surgery

This approach offers hope for a revolution in the treatment of colorectal cancer.

A groundbreaking immunotherapy drug has shown promising results in the treatment of colorectal cancer, potentially revolutionizing conventional treatments. Pembrolizumab, known as Keytruda, targets specific proteins on immune cells, effectively eliminating cancer cells. Guardian.

In a recent clinical trial led by several prominent institutions, including University College London and The Christie NHS Foundation Trust, patients with stage two or three bowel cancer who had a specific genetic profile were given pembrolizumab before surgery instead of traditional chemotherapy.

ParentsThe results, presented at the American Society of Clinical Oncology Annual Meeting, were remarkable, reporting that 59% of patients had no signs of cancer after treatment, and the remaining 41% had their cancer removed during surgery. Importantly, all patients were diagnosed with no cancer after treatment, a significant improvement over standard chemotherapy outcomes.

This approach not only increases the chances of curing the disease, but also spares patients from the often harsh side effects associated with chemotherapy. Dr. Kai-Kean Xu, lead investigator of the study, highlights that pembrolizumab triples the chances of survival if the cancer fully responds to treatment.

Although further studies are needed to establish pembrolizumab as a standard of care, early findings are very promising and suggest that it may be introduced into clinical practice within a few years. Colorectal cancer is the leading cause of cancer-related deaths worldwide and stands to greatly benefit from this therapeutic breakthrough.

Dr. Marnix Janssen, a clinician-scientist at the Institute of Cancer Research, University of London, said pembrolizumab needs further evaluation work before it can be considered a standard treatment, “but given the quality of the results from this trial, I think we could see it in the clinic within a few years if subsequent trials are similarly successful.”

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