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Gardasil 9 for the prevention of some head and neck cancers: measuring benefit

 


US Food and Drug Administration (FDA) uses Merck Sharp & Dome’s human papillomavirus (HPV) vaccine Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant) to prevent oropharyngeal and other head and neck cancers Approved by 9 different HPV strains.1 Evidence and clinical trials that the vaccine can prevent HPV-related anogenital infections (ClinicalTrials.gov identifier: NCT04199689) Evaluating its ability to prevent HPV-related throat infections in men is ongoing.

“In the United States, we are increasingly moving away from seeing cancer epidemiologically.” Dr. Glenn Hanna, a head and neck oncologist at Dana-, said: The risk of tobacco and alcohol causes the tonsils, Fewer cancers in the tongue, laryngeal, etc., but an increased prevalence of cancers caused by HPV The Faber Cancer Institute, Boston, Massachusetts.

Although no direct evidence is currently available regarding the prevention of oral and head and neck cancers with vaccines, many people find that vaccines are based on evidence of genital warts, precancerous cervical lesions, and now anal genitals. I’m pretty sure it’s likely to work with infections.

“There’s not much doubt that this vaccine is a preventive agent against oral cancer,” said Noel Brewer, professor of health behavior at the University of North Carolina at Chapel Hill. The enthusiasm for this vaccine is whether it passes all the tests required by the FDA. [for the agency] Officially approve [it].. They have a good vaccine safety testing system,” Dr. Brewer added.

Original Gardasil (human papillomavirus tetravalent) [types 6, 11, 16, and 18] Vaccine, recombinant vaccine was first approved in 2006 for the prevention of cervical cancer in girls and women, and is currently indicated for men and women aged 9 to 45 years. ..2

“The HPV subtype promotes carcinogenesis in many mucosal tissues. If a vaccine protects against the high-risk cervical cancer subtype, it makes sense to serve the head and neck. Is not a problem — I always felt that it was — but it took me a while to get support or levels of use,” Dr. Hannah said.

The American Cancer Society has also recently revised HPV vaccination guidelines.Three We encourage early vaccination of men and women starting with individuals aged 9 to 12 years, but we do not recommend HPV vaccination for people over the age of 26 due to concerns about benefits.

Some hope that the new approval for head and neck cancer prevention in men, which accounts for approximately 80% of cases of HPV-related head and neck cancer, will help increase intake in men.

“The ratio of men is about 4:1. [to] A woman at my busy head and neck academic practice. That’s the majority of our new patient population,” said Dr. Hannah.

Previously, the only approved indication for men to obtain Gardasil to prevent cancer was anogenital cancer.

“Our research on both straight men and gay men suggests that prevention against any cancer is motivating. But stigma associated with anogenital cancer may be important to providers Oral cancer is less stigmatized, and men don’t seem to care much about which cancers are being prevented,” Dr. Brewer said.

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