Health
Study finds that chronic fatigue syndrome patients have depleted T cells
Chronic fatigue syndrome causes a condition in which the immune system's ability to kill pathogens is weakened. T cells According to a new study from Cornell University, it's exhausting.
The study authors knew that the immune system is dysregulated in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), but they wondered which parts of the immune system change with the condition. I was thinking. Systematic studies have revealed that primary CD8+ T cells show one of the most prominent signs of dysregulation, showing signs of constant stimulation leading to a state of fatigue. This condition is a well-studied condition in cancer.
“This is an important discovery for ME/CFS because it means we can now examine T cells more carefully, and hopefully by looking at exhausted cells, we can get a hint of what the cells are responding to. We are looking forward to it,” said Professor Andrew Grimson. is a molecular biologist and co-corresponding author of this study. Maureen Hanson, professor of molecular biology and genetics, is the other corresponding author.
“Therapies are being developed to reverse T-cell depletion as a treatment for cancer,” Professor Hanson said. “Our findings raise the question whether such anti-fatigue drugs might also be helpful in ME/CFS.”
Strong evidence of a T-cell depletion phenomenon in ME/CFS has also been reported in long-term COVID-19 infections, Hanson added.
Immune cells from ME/CFS patients showed high levels of proteins on their surfaces, a characteristic of exhausted cells. This may be caused by long-term exposure to viral proteins or continued stimulation of the immune system. It is also seen in cancer patients. ”
Maureen Hanson, Professor of Molecular Biology and Genetics
Future research will determine whether a virus is actually involved, but it is unknown at this time. “We need to understand what is driving them into this exhausted state,” Grimson said.
The research team also plans to harvest cells from patients and controls, purify them, and treat patients with drugs that reverse fatigue to see if their immune cells regain normal function. are. If CD8+ T cell depletion can be reversed, the next question is whether such reversal would actually benefit patients, as fatigue has a protective effect.
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Reference magazines:
Aiu, DS; others. (2024). Transcriptional reprogramming stimulates CD8+ T cells toward fatigue in myalgic encephalomyelitis/chronic fatigue syndrome. Proceedings of the National Academy of Sciences. doi.org/10.1073/pnas.2415119121.
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