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India conducts late trials of two nasal Covid-19 vaccines

India conducts late trials of two nasal Covid-19 vaccines

 


Pune base Serum Research Institute The Indian government and Hyderabad-based Bharat Biotech will soon begin clinical trials of the nasal Covid-19 vaccine in India, the government said on Sunday, adding that the two pharmaceutical companies are awaiting regulatory approval. Read again- Rinsing the mouth with mouthwash for 30 seconds can inactivate 99.9% of coronaviruses

Currently, three vaccine candidates for Covid-19 are being tested in humans in India, all of which are delivered by injection.This will be my first trial Nasal coronavirus vaccine It will be done in that country. In fact, according to the World Health Organization (WHO), all vaccines currently in Phase 3 trials are given by injection. Read again- COVID-19 can lead to cranial nerve damage in children, AIIMS reports two cases

Bharat Biotech, developing India’s first vaccine candidate for COVID-19 Kovacin In collaboration with the Indian Medical Research Council (ICMR), we have signed an agreement with the University of Washington School of Medicine to test the Covid-19 vaccine for the nose. Read again- COVID-19 LiveUpdate: Indian cases surged to 75,97,063 and deaths reached 1,15,197

Under the agreement, the company will test, manufacture and sell an intranasal vaccine for SARS-CoV-2, the virus responsible for Covid-19, Health Minister Harsh Vardhan said in Sunbird on Sunday.

Phase 1 trials will be conducted at the Vaccine and Treatment Evaluation Unit at Saint Louis University in the United States. Bharat Biotech will then pursue further stages of clinical trials in India after regulatory approval, Vardhan said.

According to Vardhan, the Serum Institute of India is also working with US-based biotechnology company Codagenix to develop CDX-005, a live attenuated vaccine candidate in the nasal cavity. SARS-CoV-2. Preclinical animal studies have been successfully completed and Codagenix plans to begin Phase I human first clinical trials in the UK by the end of 2020. The Serum Institute plans to clinically develop this vaccine candidate in India.

Vardhan added that late trials of nasal vaccine candidates could involve 30,000 to 40,000 participants.

Why do you need a nasal vaccine?

Nasal vaccines are delivered through the nose. The nose is often the first part of. COVID 19 infection. Experts believe that the nasal delivery route is more effective in stopping the virus infection and preventing the infected individual from spreading the virus.

It will be more convenient not only for the use of such vaccines, but also for mass vaccinations. It also reduces costs by eliminating the need for needles and syringes. The intranasal vaccine is sprayed into the nostrils and inhaled, making it easy. Therefore, it helps reduce reliance on various trained personnel to administer the vaccine. In addition, shipping intranasal vaccines is much easier than intramuscular injection.

Nasal vaccine Excellent in stopping COVID-19 infection

Scientists at the University of Washington School of Medicine have developed a single nasal COVID-19 vaccine.Found to be effective in preventing infection in susceptible mice New coronavirus. Researchers are currently testing vaccines in non-human primates and humans.

In a report published in the journal Cell in August, researchers claimed that the nasal delivery route caused a strong immune response throughout the body, especially in the nose and airways.

They administered the vaccine to mice by two methods: nasal and intramuscular injection. The injection provokes an immune response, pneumonia, But it did not prevent nasal and lung infections. This suggests that intramuscular vaccines may reduce the severity of COVID-19, but they cannot completely stop the infection or prevent infected individuals from spreading the virus. ..

When the vaccine was delivered nasally, it prevented infections in both the upper and lower respiratory tracts, including the nose and lungs. This means that vaccinated individuals do not spread the virus or develop infections elsewhere in the body.

Intranasal approaches to vaccination have been fairly extensively tested in animals, but little evidence has yet been reached as to whether this applies to humans.

Published: October 20, 2020 14:31 | Updated: October 20, 2020 14:54




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