Health

Blocking major COVID-19 enzymes by diet

Many compounds found in certain foods, such as persimmons and berries, are known to have antiviral properties. A recent study conducted at North Carolina State University in Raleigh identified one of the common items that could help fight coronavirus disease (COVID-19) in 2019.

“One of the focus of our lab is to find ways in which the virus attaches to human cells, or dietary supplements in foods or medicinal plants that inhibit the growth of the virus in human cells,” the study said. Said De-Yu Xie, the lead author of.

Researchers have identified five crude extracts from green tea, cocoa, chocolate, and two muscadine grapes. They are rich in flavan-3-ols and proanthocyanidins (PAs), which have shown inhibitory effects on the major protease (Mpro) activity of SARS-CoV-2. .. Proteases are enzymes that break down peptides and proteins that are essential for viral health. If the main Mpro is banned, the cell will not be able to perform important functions such as duplication.

Using laboratory research and computer simulations, the team investigated how the COVID-19 Mpro reacted when one of the compounds was introduced. Computer-provided simulations, along with in vitro laboratory experiments, revealed that the compounds used in the study could bind to different parts of Mpro in COVID-19. The data also showed that the extract inhibited Mpro activity at IC50 values of 2.84 ± 0.25, 29.54 ± 0.41, 29.93 ± 0.83, 153.3 ± 47.3, and 256.39 ± 66.3 μg / ml. This indicates that the structural characteristics of flavan-3-ols are important in producing an inhibitory effect on Mpro activity.

“Green tea has five tested compounds that bind to different parts of the Mpro pocket, which essentially overwhelms them and inhibits their function,” says Xie. “Muscadine grapes contain these inhibitory chemicals in their skin and seeds. These beneficial to the leaves and skin of plants because plants use these compounds to protect themselves. Naturally, it contains compounds. “

Since no effective drug for the treatment of COVID-19 is yet available, the data found are that these dietary supplement compounds and extracts of green tea, grapes and cacao are used to support other treatments that help the pandemic. Indicates that it may be possible.

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