Health
Super-resolution cell membrane
Extended microscopy (ExM) enables imaging of cells and their components with spatial resolution well below 200 nanometers. To this end, the protein in the sample under investigation is cross-linked to a swelling polymer. Once the intermolecular interactions are disrupted, the sample can be inflated many times with water. This provides detailed insights into their structure.
“This method was previously limited to proteins. In the journal Nature Communications We are currently presenting ways to dilate lipids, or cell membranes, “said Professor Marcus Sauer, a super-resolution microscopy expert at the Julius-Maximilian University (JMU) Würzburg Biocenter in Bavaria, Germany. I am. Microbiology) and Julius Seibel (Chemistry) are also involved in this publication.
Synthetic lipids are marked and expanded
The Jürgen Cybel team has synthesized functionalized sphingolipids, an important component of cell membranes. When these lipids are added to the cell culture, they are integrated into the cell membrane. They can then be marked with a dye and swelled 4-10 times with a swelling polymer.
By combining this method with a structured illumination microscope (SIM), JMU researchers are the first to image the interaction of proteins with various membranes, including cell membranes, cell membranes, outer and inner, at a resolution of 10 to 20 nanometers. It shows that it can be converted. Membranes of intracellular organelles such as cell nucleus membranes and mitochondria.
Focus on bacteria and viruses
Sphingolipids are also very efficiently incorporated into bacterial membranes.This is the first time that the following pathogens Neisseria gonorrhea, Chlamydia trachomatis And Flammeovirgaceae negevensis It is now possible to visualize within infected cells at a resolution that was previously achieved only with an electron microscope. Even the intima and adventitia of Gram-negative bacteria can be distinguished from each other.
“We want to use new super-resolution microscopy to investigate the mechanism of bacterial infections and the causes of antibiotic resistance. What we have learned in the process may help improve treatments,” said Bacterial infections. Expert Professor Thomas Rudel said.
Sphingolipids can also be incorporated into the viral membrane. If this is successful, the interaction of coronavirus with cells can be studied for the first time with a high-resolution light microscope.
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