Health

Studies have shown that a second dose of COVID-19 vaccine is safe after an allergic reaction to the first dose.

Studies have shown that immediate-onset mRNA vaccine responses may not have been caused by classical allergies or IgE-mediated hypersensitivity.

According to researchers at Massachusetts General Hospital (MGH), any person who has had an allergic reaction to the first dose of messenger RNA (mRNA) COVID-19 vaccine will receive it in the second dose. Well tolerated.

According to a study published in, reported allergic reactions to the first dose of mRNA vaccine reached as high as 2%. JAMA International Medicine.. Anaphylaxis occurs in up to 2.5 of 10,000 vaccinated people, but researchers point out that reactions can take many forms.

“These reactions can include symptoms such as itching, hives, and flushing,” said Matthew S. Kranz, MD, co-author of the Vanderbilt University Medical Center, in a press release. .. “Patients included [in the study] After the first reaction, I received all the advice from an allergy expert. “

Of the 189 patients included in the analysis, 32 (17%) experienced anaphylaxis after the first dose of the vaccine and 159 (84%) continued to receive the second dose. All of these patients, including 19 who experienced anaphylaxis after the first dose, tolerated the second dose. Specifically, 32 patients (20%) reported immediate potential allergic symptoms that were self-limited, mild, and resolved with antihistamines alone.

“One of the key points of this study is that these immediate-onset mRNA vaccine responses may not be mechanically triggered by a classic allergy called immediate-onset hypersensitivity or IgE-mediated hypersensitivity. That’s what co-chief author Kimberly G. Blumental, MD, said. In a press release, Director of the Clinical Epidemiology Program in the Department of Rheumatoid Arthritis, Allergy and Immunology at MGH. “In the case of classic allergies, re-exposure to the allergen causes the same or even worse symptoms.”

Importantly, these findings suggest that most people are safe to receive a second dose of the mRNA COVID-19 vaccine, according to the authors of the study.

Aleena Banerji, MD, Clinical Director of the MGH Allergy and Clinical Immunology Unit, said in a press release:

reference

A second dose of COVID-19 mRNA vaccine was found to be safe after an allergic reaction to the first dose. news release. Massachusetts General Hospital; July 26, 2021. Accessed on August 5, 2021. https://www.massgeneral.org/news/press-release/Second-COVID-19-mRNA-vaccine-dose-found-safe-following-allergic-reactions-to-first-dose

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Studies have shown that a second dose of COVID-19 vaccine is safe after an allergic reaction to the first dose.