Health
Genetic analysis suggests why COVID-19 spoils odors
For many, one of the fastest tips to have COVID-19 is the loss of taste and odor. Researchers have now identified some genetic variants in people who are likely to have coronavirus deprivation of these sensations.
In a study of about 70,000 adults with COVID-19, individuals with specific genetic tweaks to chromosome 4 were found. 11% more likely to lose your sense of smell and taste Researchers report January 17th, than those who haven’t changed Nature Genetics.. The data are from people whose DNA was analyzed by genetic testing company 23andMe and self-reported cases of COVID-19.
Two genes, UGT2A1 When UGT2A223andMe epidemiologist Janie Shelton et al. Help people’s odors to be present in regions of chromosome 4 associated with sensory loss during infection. Both genes make enzymes that metabolize substances called odorants that give off a unique odor.
Studies suggest that the loss of odor, a characteristic symptom of COVID-19, is due to the colonization of the infection. Cells that support the sense of smell Called sustentacular cells (SN: 6/12/20).Genetic variation may be nearby UGT2A1 When UGT2A2 Shelton said that when infected, the two genes can be turned on and off, which can somehow disrupt the sense of smell.
Because the team combined olfactory and taste loss in a single research question, this study cannot analyze whether genetic variation is involved in one sensory loss. “Loss of smell often results in a significant loss of taste,” says Shelton. The taste can also disappear without losing the odor.
Some people continue to lose their odor even after the coronavirus leaves the body, says Shelton. Understanding how the virus snuffs the ability of snuffs can help researchers find ways to regain it.
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