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UT researchers say general treatment of influenza could be the key to delaying a pandemic

 


Austin (KXAN)-A new study by the University of Texas on the efficacy of antiviral agents sheds new light on the efficacy of these agents in inhibiting viral spread. In this study, we modeled how valoxavir, an antiviral agent commonly known as Xofluza, can reduce influenza virus infection. Using this model, more than 6,000 deaths could have been prevented during the 2017-2018 flu season if 30% of infected people received valoxavir within 48 hours of infection. I understand. Researchers point to this model as an indication that antiviral drugs may be effective in combating COVID-19.

Mass production of antivirals is more viable than mass production of vaccines, according to retired University of Texas professor Robert Krug. Krug, who did the research that led to the development of valoxavir 40 years ago, says valoxavir works by preventing the reproduction of the virus. “If you give valoxavir within a day, the virus is essentially gone,” says Krug. “What it does is reduce the time it takes for a person to become contagious.”

“You want a drug like CoVid-19,” Krug says. He says the development of antivirals takes time, but there is an interest and desire for antivirals.

Krug said that he and other researchers are now looking into the current FDA-approved antiviral drugs that could be used to combat COVID-19. He says he has isolated one compound that could lead to a COVID-19 antiviral drug, but further testing is needed first.

According to Krug, one of the benefits of considering a drug that has already been approved by the FDA is that it does not require rigorous testing. This could mean that these antivirals may reach the market sooner.

Antiviral drug vs vaccine

“Everyone has this idea and is devoted to vaccination,” says Krug. “Obtaining a vaccine is a great idea, but it’s not an easy task.” Krug said that antivirals are superior to vaccines because antivirals are easier to manufacture and faster to develop. It means that

Vaccines currently being studied It focuses on attacking the spikes that make up the coronavirus crown. These spikes allow the virus to attach to human cells. Building a vaccine that attacks only these spikes has no effect, says Krug.

“I think they should focus more on these antiviral drugs,” says Krug. “Because they are faster. We know all the techniques. It’s always done.”

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