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Black Hispanic women with vitamin D deficiency may be at increased risk of breast cancer

Black Hispanic women with vitamin D deficiency may be at increased risk of breast cancer

 


April 25, 2022

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Disclosure: One author reports support for travel / conference attendance from NIH.


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Black / African-American and Hispanic / Latin women with low vitamin D levels may be more likely to be diagnosed with breast cancer than women with appropriate levels, according to a study published in. cancer..

“Along with previous studies on this topic, this article suggests that vitamin D may be associated with reduced risk. [for] Breast cancer, including blacks, African-Americans, Hispanics, or women who identify themselves as Latina. ” Katie M. Dr. O’Brien, A staff scientist in the epidemiology department of the National Institute of Environmental Health Sciences said in a press release.


Hazard ratio based on race and ethnicity.
O’Brien KM, et al. Data obtained from. cancer.. 2022; doi: 10.1002 / cncr.34198.

Background, methodology

Studies have shown that vitamin D may prevent breast cancer, but few studies have investigated this potential association. Black / African American and Hispanic / Latin WomenPeople who tend to have lower levels of circulating 25-hydroxyvitamin D than Caucasian women.

Dr. Katie M. O'Brien

Katie M. O’Brien

In the current study, O’Brien and colleagues obtained blood samples from participants in a national sister study cohort, including 415 women who were later diagnosed with breast cancer and 1,447 women who did not develop breast cancer. The group had similar proportions of black / African American (70%) and Hispanic / Latino (30%) women.

Researchers used liquid chromatography-tandem mass spectrometry to measure circulating 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in blood samples collected at enrollment.

The average follow-up period was 9.2 years.

result

The results showed a 21% lower breast cancer rate among women with vitamin D levels above clinical levels. Insufficient cut point (20 ng / mL) Compared to people with concentrations below 20 ng / mL (HR = 0.79; 95% CI, 0.61-1.02).

Researchers found that among Hispanic / Latin women (HR = 0.52; 95% CI, 0.29-0.93), a stronger reverse than black / African American women (HR = 0.89; 95% CI, 0.68-1.18). I observed the correlation. They found no obvious differences based on menopausal status, follow-up time, ER status or invasiveness.

Implications

According to researchers, the findings reveal potential paths for intervention between members of these racial and ethnic groups.

“Women identified as members of these groups have lower vitamin D levels on average than non-Hispanic white women, so interventions that promote vitamin D intake may increase health benefits.” O’Brien said in a press release. “But the question remains whether these associations are really causal, and if so, what level of vitamin D is most beneficial.”

Sources

1/ https://Google.com/

2/ https://www.healio.com/news/hematology-oncology/20220425/black-hispanic-women-with-vitamin-d-deficiency-may-be-at-higher-risk-for-breast-cancer

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