Health
Impact of SARS-CoV-2 infection during pregnancy on infant growth
manuscript of a recently accepted article published in Journal of Clinical Endocrinology and Metabolism We described recent findings on the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy on infant growth.
study: The past is the prologue. Growth of infants born from pregnancies complicated by SARS-CoV-2 infection. Image Credit: MIAStudio/Shutterstock.com
Background
SARS-CoV-2 infection during pregnancy raises concerns about the potential risk of fetal infection and a hostile uterine environment for the growing fetus.
Recognition of the urgent need for research in this area has led to longitudinal studies on the impact of coronavirus disease 2019 (COVID-19) during pregnancy and the development of biorepositories.
COVID-19 can cause a plethora of complications during pregnancy, including prematurity, preeclampsia, gestational hypertension, and an inflammatory systemic environment, which can impact the lifelong health of the infant.
Infant growth from pregnancies complicated by COVID-19
A recent study compared longitudinal trajectories of height, weight, and body mass index (BMI) between one and no infants. intrauterine Exposure to SARS-CoV-2.
The researchers excluded mothers who were vaccinated during the study period to reduce heterogeneity. In this study, we found that infants exposed to SARS-CoV-2 had lower her BMI at birth than unexposed infants, even after adjusting for gestational age and associated covariates.
Exposed infants have a rapid increase in BMI during infancy
Notably, BMI increased rapidly in exposed infants in the first year of life after considering factors affecting BMI.
Also, this postnatal increase in BMI was most rapid in those born to patients with severe COVID-19. Statistical analysis revealed that most of the effects of COVID-19 on postnatal BMI increase were mediated by low birth weight. Small changes in length were noticeable but not statistically significant.
Measuring infant height is difficult and can be prone to error in clinical and research settings. Collection of research data and larger samples may therefore lead to a better understanding of the effects of exposure to SARS-CoV-2 on infant development.
A multinational study of newborns with and without intrauterine Newborns turned out to be tiny as a result of their exposure to COVID-19. It negatively affects weight, head circumference and length.
Previously, the authors of this study observed that infants born with low BMI increased rapidly postnatally, and poverty and tobacco exposure were associated with postnatal BMI ‘catch-up’. I noticed that In addition, epidemiological studies have reported an association between low birth weight and excessive cardiometabolic risk later in adulthood.
However, they have not established a causal relationship between rapid weight gain in infants and adverse outcomes later in life. Socioeconomic disparities that adversely affect health throughout the life cycle may contribute to this pattern.Therefore, understanding the long-term risks associated with rapid weight gain in infants exposed to COVID-19 intrauterine has not yet been determined.
Therefore, further research is needed to understand how long the effects of prenatal COVID-19 persist after birth. Furthermore, identifying protective factors may lead to strategies to enhance preventive care in subsequent infants. intrauterine SARS-CoV-2 exposure.
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