Health
Post-sleep binocular visual stimulation helps treat common visual impairments in children
Amblyopia, sometimes called lazy eye, is a common vision problem in children and babies, usually by having a child’s strong eye wear a patch to improve vision in the weaker eye. have been treated.
Recent research suggests that treatments that require the eyes to work together may accelerate recovery in people with amblyopia. Other studies have shown that getting the right amount of sleep can help repair or rebuild neural networks in the brain, especially in children, said Sarah Atton, a researcher at the University of Michigan. .
Aton’s lab combined two research questions to find that visual stimuli given to both eyes, rather than just the amblyopic mice, could help them experience a more complete recovery of visual function. I found For even better results, mice had to be put to sleep immediately after the rich visual experience. The team’s results are published in Communications Biology.
Current standard practice for treating children, and perhaps adults, with amblyopia may have room for improvement. ”
Sara Aton, Associate Professor of Molecular, Cellular and Developmental Biology
First, our findings suggest that patch therapy, which has been routinely used for decades, may be inferior to recently developed methods aimed at getting the eye to work together. It suggests that there is
“Second, attention to the child’s sleep timing with respect to this therapy suggests that it is easy to implement and may have very large benefits regarding therapeutic potential.
To study amblyopia, the researchers looked at mice with the same type of long-term loss of visual information processing that occurs in the brains of children with amblyopia. A rich visual stimulus was presented to the mice. Mice could either close their stronger eye mimicking patch therapy or keep both eyes open simultaneously.
Researchers have found that binocular visual stimulation (looking at both eyes together) increases brain plasticity. Additionally, they tested the importance of sleep in this therapy. Some of these benefits were reversed when mice were put to sleep but sleep was disrupted in the first few hours after visual stimulation.
Their findings suggest that patch therapy, which has been routinely used for decades, may be inferior to recently developed methods aimed at getting the eye to work together. The study also suggests that paying attention to the timing of children’s sleep with respect to this therapy is easy to implement and may have very large benefits regarding therapeutic potential. .
“We hope this will open new avenues for clinicians to test pediatric patients. It’s a lot,” said Aton. “Patch therapy has been the standard of care for decades.
“Since then, our technical competence in visual therapy has improved, as has our understanding of how sleep contributes to the development of brain function. treatment options will be seen.”
UM co-authors also include Jessy Martinez, Marcus Donnelly, Donald Popke, Daniel Torres, Lydia Wilson, William Brancaleone, Sarah Sheskey, Cheng-mao Lin, Brittany Clawson, and Sha Jiang.
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Journal reference:
Martinez, JD, others(2023). An enhanced binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia. communication biology. doi.org/10.1038/s42003-023-04798-y.
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