Fasting Diet and Hormone Therapy May Help Treat Breast Cancer: Research-Health

According to a team of international scientists led by the USC, a fasting diet combined with hormone therapy may help treat breast cancer.

In a mouse study and two small breast cancer trials, researchers at the IFOM Cancer Institute in USC and Milan collaborate with the University of Genova on a fasting mimetic diet to reduce blood insulin, insulin-like growth factor I have found that 1 (IGF1) and leptin.

In mice, these effects appear to increase the potency of the cancer hormone drugs tamoxifen and fulvestrant and delay their resistance. The results of 36 women treated with hormonal therapy and a fasting diet are promising, but researchers find it still premature to determine if they will work in a large clinical trial. say.

The study was published in Journal Nature.

“Our new study suggests that a fasting diet along with endocrine therapy for breast cancer not only shrinks the tumor, but may reverse resistant tumors in mice.” USC Leonard Davis Geriatrics Professor of Biological Sciences at the University of the Arts in Dunlucife, USC at the Longevity Institute.

“We have the first data to suggest that a fast-mimicking diet works by modifying at least three different factors: IGF1, leptin and insulin,” added Longo.

The researchers say the two small clinical trials are feasibility studies with promising results, but they are by no means conclusive. They believe that the results support further clinical studies of a fasting mimetic diet used in combination with endocrine therapy in hormone receptor-positive breast cancer.

Scientists have also contributed to a recent clinical study of 129 breast cancer patients conducted at Leiden University. Results published last month at Nature Communications appear to indicate improved efficacy of chemotherapy in patients receiving a combination of chemotherapy and fasting diet.

Two new small clinical trials-one of which was directed by study co-author Alessio Nencioni-metabolism of hormone receptor-positive breast cancer patients undergoing cycles of estrogen and fasting diet It seemed to experience similar changes to those observed in mice.

These changes included reduced levels of insulin, leptin, and IGF1, with the last two remaining low over time. In mice, these long-term effects are associated with long-term anti-cancer activity and require further study in humans.

“Some patients followed the fasting mimicry monthly cycle for almost two years without any problems, suggesting that this was a well-tolerated intervention. I hope this nutritional program, which mimics, will someday be a better weapon to fight cancer in patients undergoing hormone therapy without significant side effects,” Nencioni said.

“The results in mice are very promising. And while early clinical results show promise, we need to confirm that it works in trials of 300-400 patients,” Longo said. Explained.

The data also suggest that in mice, a fasting diet appears to prevent tamoxifen-induced endometrial hyperplasia, a condition in which the endometrium (or uterine lining) is abnormally thickened. I am. The authors of the study believe that this potential use of a fasting diet should be further explored given the prevalence of this side effect of tamoxifen and the limited options to prevent it.

About 80% of all breast cancers express estrogen and/or progesterone receptors. The most common form of hormone therapy for these breast cancers works by blocking hormone attachment to cancer cell receptors or by reducing the body’s hormone production. Endocrine therapy is often effective in these hormone receptor-positive tumors, but long-term benefits are often hampered by treatment resistance.

Several clinical trials in the USC, including breast cancer and prostate patients, have investigated the effects of a fasting diet in combination with various anticancer agents.

“I want to call it a non-toxic wildcard for the treatment of cancer. These clinical studies we just published, like many animal studies published in the last 12 years, show that Every cycle, different factors or nutrients are important for cancer cell survival,” said Longo.

(This article has been published from the telegraph agency feed with no changes to the text. Only the headings have changed.)

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