Health
Coronavirus-related childhood illness associated with blood cell changes
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A newly reported disease associated with COVID-19 that occurs in children involves large changes in white blood cells. This is a finding that doctors may be able to better assess the condition of younger patients and predict resistance to current treatments.
New Childhood Inflammatory Multisystem Syndrome Associated Temporarily with SARS-CoV-2 Infection (PIMS-TS) disease It shares some characteristics with Kawasaki disease and toxic shock syndrome.
The expert Children Hospitalized for illness in Birmingham Children’s Hospital during the UK Coronavirus Lockdown-PIMS-TS and discover major changes in monocytes (a type of white blood cell) in patients with Kawasaki disease.
British and Irish scientists and healthcare professionals, led by researchers at the University of Birmingham, have published their findings as a preprinted paper on medRxiv.
Co-author Dr. Graham Taylor of the Institute of Immunology and Immunotherapy at the University of Birmingham comments: Monocytes and their genetic makeup. Although the results require confirmation in a larger patient cohort, the changes observed are likely to be highly relevant and may predict PMS-TS and Kawasaki disease child resistance. You can also identify alternative therapies for both disorders. “
Researchers recruited nine children with signs of PIMS-TS, presented at a Women’s and Children’s Hospital in Birmingham between April and May 2020, to the study. Antibody positive. Two children met the criteria for Kawasaki disease and were SARS-CoV-2 antibody negative.
Dr. Barneys Caulfield, Pediatric Intensive Care Consultant, NHS Foundation Trust, Birmingham Women and Children’s Hospital, commented: The Birmingham team quickly conducted a novel and detailed analysis to identify potential treatment targets. The state-of-the-art approach used assists future children affected by COVID19. “
Ribonucleic acid (RNA) sequencing has allowed specialists to identify large changes in the frequency of classical, intermediate, and nonclassical monocytes that occur in both diseases.
Viral causes of SAV-CoV-2, COVID-19 usually cause mild respiratory infections in children and young adults. However, in rare cases, the child subsequently develops PIMS-TS, with evidence of fever, inflammation, organ failure, and heart failure, low blood pressure, and life-threatening shock.
PIMS-TS shares clinical features with Kawasaki disease, a vascular inflammation that affects children under 5 years of age. Kawasaki disease, which can cause myocardial inflammation if left untreated, is the leading cause of acquired heart disease in children in developed countries.
Given the recent emergence of PIMS-TS, little is known about the immunological processes that cause the disease and whether these are similar or different from Kawasaki disease.
Eleni Syrimi et al. Single-cell RNA-seq reveals profound monocyte alterations in childhood inflammatory multisystem syndrome transiently associated with SARS-CoV-2 infection (PIMS-TS), (2020). DOI: 10.1101 / 2020.08.06.20164848
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University of Birmingham
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