Health
Suicide increased following FDA framed warnings on antidepressants
The US Food and Drug Administration (FDA) regularly issues framed warnings. Antidepressant Regarding the risk of suicide, it may affect the suicide tendency of adolescents and young adults.
A team led by Christine Y. Lu, PhD, MSc, Harvard Medical School of Medicine, and Harvard Pilgrim Healthcare Institute uses 28 years of national death certificate data to increase suicide deaths following FDA warnings. And I investigated if the treatment for depression was reduced.
In 2003, the FDA issued a public health recommendation that children and adolescents taking antidepressants are at increased risk of suicidal ideation and behavior. The FDA then issued a more serious “framed warning” in 2005 about the risks involved in all antidepressant labeling.
Past studies have shown that depression diagnoses, psychotherapy, medications have decreased, and suicide attempts have increased, following FDA antidepressant warnings about the risk of suicide in young people. These effects on care also extend to older people suffering from mental illness.
Investigators conducted an interrupted time-series study of mortality data validated between 1990 and 2017 in the United States per 100,000 adolescents aged 10-19 and young adults aged 20-24 after warning. Estimated changes in suicidal mortality tendencies. We also controlled baseline trends.
Prior to the FDA’s warning (1990-2002), suicide deaths were significantly reduced. However, following the warning (2005-2017), suicide deaths increased significantly with a sharp decline in treatments.
Investigators also found that 0.49 suicides per 100,000 adolescents increased immediately (95% CI, 0.12-0.86) and 0.03 suicides per 100,000 adolescents tended to increase annually. (95% CI, 0.026-0.031).
The research team also found an immediate increase in 2.07 suicides per 100,000 young adults (95% CI, 1.04-3.10) and an increased propensity for 0.05 suicides per 100,000 young adults (95% CI, 0.04-). 0.06) was found. Assuming continued baseline trends, it is possible that by 2010 there were as many as 5958 excessive suicides nationwide between an annual cohort of 43 million adolescents and 21 million young adults.
“We have observed an increase in the number of suicides among adolescents who have been warned and a decrease in treatment for depression. Other explanations have been considered, including substance use, recession, smartphone use, and death from unintentional injury.” The author writes. “Additional factors may have contributed to the continued increase in adolescent suicide over the last decade. Combined with previous studies on reduced treatment, these results are antidepressant warnings. Needs reevaluation. “
Depression is currently the leading cause of adolescent suicide, but adolescent suicide increased by more than 50% between 2003 and 2017.
Over 60% of adolescents experience major depressive episodes and are mentally with a general counselor or mental health clinician during the year when they are not receiving front-line evidence-based treatment such as psychotherapy, including cognition. I have never had a health encounter. , Behavior therapy, interpersonal therapy, or antidepressants as needed.
It has long been known that appropriate treatment can improve the health outcomes of this patient population.
the study, “US Food and Drug Administration Framed Warnings for Antidepressants and Increasing Number of Adolescents and Young Adults Suicide After Decline of Depression Treatment, ”Was published online Psychiatric research and clinical practice..
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