Health
New study quantifies life expectancy in IBD patients
on the other hand Inflammatory bowel disease (IBD) can be fatal, and it is not entirely known what the life expectancy of a sick patient is.
A team led by M. Ellen Kuenzig, PhD, Division of Gastroenterology, Hepatology and Nutrition (Benchimol), and The Hospital for Sick Children determines life expectancy and health-adjusted life expectancy trends in patients with and without IBD. did.
In a retrospective cohort study, investigators used population-level health care, demographics, and health survey data available from the Ontario database. The research team then matched patients diagnosed with IBD with healthy controls and used life tables generated with 5-year mortality rates by age and gender, 1996, 2000, We calculated life expectancy for 2008 and 2011.
Investigators also incorporated the Health Utility Index (National Population Health Study; Canadian Community Health Survey) to estimate health-adjusted life expectancy in 1996, 2000, and 2008.
Overall, the data show that life expectancy in IBD patients increased between 1996 and 2011 (female: 75.5-78.4 years, difference, 2.9 years, 95% CI,). 1.3-4.5, male: 72.2-75.5 years, difference, 3.2 years, 95% CI, 2.1-4.4).
They also found that health-adjusted life expectancy decreased by 3.9 years (95% CI, 1.2-6.6) among men between 1996 and 2008.
However, there were no statistically significant changes in women’s width IBD health-adjusted life expectancy (difference, 2.0 years, 95% CI, -1.6 to 5.7).
Life expectancy in patients with IBD and health-adjusted life expectancy were also lower when compared to healthy controls.
The difference in life expectancy between the two groups in the study ranged from 6.6 to 8.1 years for women and 5.0 to 6.1 years for men, depending on the year.
Differences in health-adjusted life expectancy between the two groups ranged between 9.5 to 13.5 years for women and 2.6 to 6.7 years for men.
“Although life expectancy for people with IBD is increasing, there remains a life expectancy gap between people with and without IBD, and the impact of pain on daily function is a health-adjusted reduction in life expectancy. This has contributed significantly to the need to improve pain relief strategies. It has been implemented, “the author writes.
In recent years, IBD management has increased access to professional care, as well as biotherapy and therapeutic-to-target approaches, including treatments aimed at minimizing inflammation and preventing disease progression. It has been improved by popularization.
Biologics improve a patient’s quality of life, but they can also increase the risk of serious infections and malignancies, especially in older patients. IBD management and medication changes can affect life expectancy and quality of life.
Researchers have also recently found a higher mortality rate for patients with Crohn’s disease when compared to the general population. However, studies assessing ulcerative colitis mortality were not conclusive.
In addition, most studies assessing mortality in IBD patients were conducted before the biological age, but none assessed life expectancy or health-adjusted life expectancy.
the study, “Life Expectancy and Health-Adjusted Life Expectancy for People with Inflammatory Bowel Disease, ”Was published online CMAJ (Canadian Medical Association Journal)..
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