Health

Promising MS Drugs Can Exacerbate Disease-ScienceDaily

Drugs that have shown promising treatments for multiple sclerosis can actually exacerbate debilitating illness, a new study from the University of Virginia School of Medicine suggests.

The drug has not yet been tested on humans in MS, but UVA scientists warn fellow researchers to proceed very carefully. In addition to exacerbating the disease in the mouse model, they report that the drug also had unintended, untargeted effects.

“That wasn’t what we expected,” said Dr. Alban Gaultier, an MS researcher at UVA’s Department of Neuroscience and its Brain Immunology and Glia Center (BIG). “The message of take-out is that we need to be very careful and do more basic research before we propose to bring it into clinical trials.”

About multiple sclerosis

Multiple sclerosis is a debilitating autoimmune disease that affects an estimated 1 million Americans. The disease causes the body’s immune system to destroy myelin, the insulator that surrounds and protects our nerve fibers. This prevents nerves from sending signals to the brain. Injuries can cause a variety of symptoms, including muscle spasms, malaise, difficulty moving, numbness, and pain. These symptoms vary from patient to patient.

Because existing multiple sclerosis drugs have unwanted side effects, such as impairing the body’s ability to fight infections, doctors are keen to develop better alternatives. One of the promising candidates is a small molecule drug called TEPP-46. Originally developed to combat cancer, TEPP-46 targets what is known as “metabolic adaptation” (a change in the way cells generate energy) that occurs in both cancer and multiple sclerosis. I will.

However, in Gaultier’s MS model, TEPP-46 exacerbated the disease and redirected inflammation from the spinal cord to the brain. He and his team do not fully understand why, but he and his collaborators have determined that the drug has caused harmful changes in immune cells called T cells. There was also an unexpected “off-target” effect. This means that the drug affected cellular processes other than intended.

Gaultier said his findings were in conflict with other studies and that further research was needed before scientists could transfer the drug to clinical trials in people with multiple sclerosis. ..

One of the benefits of the new study suggests that TEPP-46 could be used to create better mouse models of MS and help scientists understand and treat the disease. That is.

“It’s something that could be very helpful,” Gaultier said. “In this animal model of MS, most of the inflammation occurs in the spinal cord, so the drug could be used to reprogram immune cells to transfer the condition from the spinal cord to the brain. It better mimics human illness. “

Story source:

material Provided by University of Virginia Health System.. Note: The content can be edited in style and length.

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

Pictures Credit