Health
Early use of biopharmacy is recommended for patients with Crohn’s disease who form lumens and fistulas
Crohn’s disease, a type of inflammatory bowel disease (IBD) that causes inflammation of the gastrointestinal tract (pain and swelling), can cause daily health problems, frequent hospitalizations, and surgery if not properly managed. there is. There is no cure for Crohn’s disease, but there are treatments that can help patients lead an asymptomatic life.
After a detailed review of the available literature, the American Society of Gastroenterology (AGA) has published new clinical guidelines outlining the benefits and risks of each drug currently available to patients with Crohn’s disease. Based on this study, AGA recommends early introduction of biopharmacy to patients experiencing Crohn’s disease, which forms lumens and fistulas, rather than waiting for other treatments to fail. These guidelines are Gastrointestinal illness, AGA’s official journal.
As many new drugs enter the market, the ability of clinicians to treat patients with Crohn’s disease has improved significantly over the last two decades. We hope that this new guideline will serve as a manual for clinicians to choose the right treatment for their patients. This improves patient outcomes and reduces the need for invasive surgery... “
Joseph D. Feuerstein, MD, Study Lead Author, Beth Israel Deaconess, Massachusetts University
Key Guidelines Recommendations:
- 1. Biopharmacy is the most effective drug for the management of Crohn’s disease and may delay its use in patients with moderate to severe or fistular Crohn’s disease until after the failure of mesalamine and / or corticosteroids. It should be used early. These drugs are antibodies that can more accurately target the immune system that is causing the inflammation of Crohn’s disease.
a. Anti-tumor necrosis factor (anti-TNF) agents or ustekinumab are recommended, and vedolizumab is suggested as first-line treatment.
b. For patients who have not previously responded to anti-TNF agents, AGA recommends ustekinumab or vedolizumab.
c. Biological natalizumab is no longer recommended due to potential adverse events and the availability of safer treatment options.
Source:
Journal reference:
Feuerstein, JD, et al.. (2021) AGA clinical practice guidelines for medical management of moderate to severe luminal and perianal anal fistula Crohn’s disease. Gastrointestinal illness.. doi.org/10.1053/j.gastro.2021.04.022..
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