Health
100 Years Old Tuberculosis Vaccine May Protect Elderly People From COVID 19: ICMR
Vaccines that have been used to treat tuberculosis for the past 100 years may help prevent the risk of Covid-19 infection in the elderly, according to a study by the Indian Medical Research Council (ICMR).
Bacillus Calmette-Guerin (BCG) is considered one of the most widely used vaccines in the world, with approximately 130 million babies receiving this vaccine each year. There is growing interest in BCG vaccination among the elderly, especially in countries where many cases of Covid-19 have been reported.
Previous studies have reported that BCG vaccination may provide protection against respiratory tract infections, including viral infections.
A new study published in the journal Science Advances suggests that BCG may act to inhibit biomarkers of inflammation by immune cells in the blood.
However, “this has not yet been proven, and it is still unclear how long this inhibitory effect can last,” said a team of researchers at the ICMR-National Tuberculosis Institute and the ICMR-National Epidemiology Institute. rice field. ..
In addition, the study also found that recent BCG vaccination was not associated with hyperinflammation, but was then down-regulated, which may play a protective role in the elderly population against inflammatory diseases. It is reported that it was associated with the basal inflammatory condition.
In addition, the researchers said it is quite possible that the pathogen-specific immune response is unaffected by BCG vaccination, or in contrast, is actually enhanced.
Apart from various inflammatory cytokines that can play a detrimental role in Covid-19, anti-inflammatory reactions such as IL-10 and IL-33 (related to the severity of Covid-19) are also vaccinated. Decreased in individuals who received.
“In conclusion, the current study emphasizes that the effects of BCG vaccination are safe and do not result in increased inflammation in the elderly. The results of this study support the immunomodulatory properties of BCG vaccination. Not only () the specific immunogenicity of BCG vaccination against systemic inflammation, “the researchers said.
The study also found certain restrictions, such as the lack of a placebo control group (only unvaccinated controls at baseline).
A better understanding of the results could support the effectiveness of the vaccine and explore innovative applications of the BCG vaccine, the team said.
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