COVID-19-induced thyroid infection confirmed in an Italian patient

Data from a new case study by an Italian hospital investigator Coronavirus Disease 2019 (COVID-19) May cause subacute thyroiditis.

Based on the chronological association observed in an 18-year-old patient, hospital clinicians suggest that SARS-CoV-2 is believed to be responsible for the development of subacute thyroiditis in the patient.

“We reported the first case of subacute thyroiditis after SARS-CoV-2 infection,” said Dr. Francesco Latrofa, a principal investigator at the University of Pisa Hospital in Pisa, Italy. In the statement.. “Doctors need to be alerted to the potential for this additional clinical symptom associated with COVID-19.”

Published in Journal of Clinical Endocrinology & Metabolism, The study on page 12 outlines what researchers suggest as the first example of subacute thyroiditis caused by COVID-19. An 18-year-old woman who received an oropharyngeal swab for SARS-CoV-2, just two days after her father, who lived on February 28, 2020, was hospitalized for COVID-19.

Over the next few days, the patient developed rhinorrhea and cough, which the researchers classified as mild. These were left untreated and the patient recovered completely in 4 days. The patient then underwent two additional SARS-CoV-2 swabs on March 13 and March 14. Both of these swabs returned negative.

Following a negative swab, the patient suddenly developed a fever of 99.5 ° F, fatigue, palpitation, and anterior neck pain extending to the jaw. Due to this pain, the patient was referred to the University of Pisa Hospital on March 19.

A physical examination at the hospital showed a heart rate of 90 beats per minute. On palpation, the thyroid gland was enlarged, slightly tender, and extremely painful. Laboratory tests showed high levels of free thyroxine (FT4) and free triiodothyronine (FT3), undetectable TSH, and elevated inflammatory markers and white blood cell counts. Ultrasonography of the neck performed in the hospital showed bilateral and diffuse hypoechoic areas.

Of note, examinations from February 20, 2020 showed normal thyroid function and imaging. When treated with 25 mg / d prednisone, the patient’s fever and neck pain subsided within 2 days and the remaining symptoms resolved within 1 week. A follow-up visit on April 27 restored normal thyroid function tests and inflammatory markers.

“To our knowledge, this is the first case of SAT associated with SARS-CoV-2. We believe that SARS-CoV-2 is responsible for the development of subacute thyroiditis because of the time series association. It may have been. “

This study “Subacute thyroiditis after SARS-CoV-2 infection” Published in Journal of clinical endocrinology and metabolism.

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