Health
New studies show that diabetes medications can be a game changer for obesity
According to a new study, drugs recently approved for the treatment of type 2 diabetes are also very effective in reducing obesity.
This drug, called tyrzepatide, helps control blood sugar levels and acts on two natural hormones involved in sending satiety signals from the intestines to the brain...
Researchers have also noticed that people who took medicine because of diabetes also lost weight. The new trial focused on people suffering from diabetes-free obesity and also losing weight.
Those taking the highest of the three doses studied lost 21% of their body weight and, in some cases, 50-60 pounds.
Dr. Robert Gabey, Chief Scientific Medical Officer of the American Diabetes Association, said that nothing else has resulted in such weight loss other than surgery. The full study was presented at ADA’s annual conference in New Orleans on Saturday. Published in The New England Journal of Medicine..
Another obesity treatment approved last year, called semaglutide from Novo Nordisk, results in an average weight loss of up to about 15%.Previous Generations of diet medicines have lost only about 5% of body weight, and many have had exorbitant side effects.
“There was no such tool,” says Gabbay. “I think it’s really exciting.”
The side effects of tyrzepatide were not serious for most of the clinical trial participants, said Jeff Emic, vice president of product development for the diabetes division of Lily, the leading pharmaceutical company that manufactures the drug.
About 15% of participants who received the active ingredient dropped out of the 72-week study, and about one-third dropped out due to gastrointestinal side effects. Meanwhile, 26% of study volunteers who received placebo dropped out. Emic said she suspects she may be dissatisfied with her not losing weight.
May 13th Food and Drug Administration Approves TirzepatideUnder the trade name Mounjaro, for the treatment of type 2 diabetes.
Tirzepatide is not yet available for weight loss, but Lily wants to submit data to the FDA later this year, Emic said. Regulators complete Lily first with tyrzepatide in obese and diabetic people and other studies considering adding lifestyle changes to drug prescribing before approving drugs for weight loss You may want to do it.
Weight loss of 15% to 20% or more could change the way doctors treat diabetes from focusing on lowering blood sugar levels to aiming for complete remission, Gabey said.
Ann Previous study of tyrzepatide in diabetes Half of the participants in the early stages of diabetes showed remission while taking the drug.
“This could significantly change the way we think about how to treat people with type 2 diabetes,” he said.
What is not yet known is whether remission is achieved in this way reduces the typical complications of diabetes, such as cardiovascular disease, nerve and kidney damage, and amputation of limbs.
It is still unclear whether tyrzepatide will provide the cardiovascular benefits that semaglutide provides, said Dr. David Lind, primary care physician and chief medical officer at the Boston-based Institute for Clinical Economic Review.
According to Rind, it’s beneficial to compare the two medicines directly to see if there are any differences in health benefits.
“The question is whether tyrzepatide is one step better than all those (other weight loss) drugs,” Lind said. “There’s a reason to think it might happen, but I don’t think it’s been proven yet.”
Positive side effects
It certainly made a difference to Mary Brühl, 63, in Norman, Oklahoma.
She participated in a tyrzepatide diabetes trial in August 2019 because she heard that weight loss could be a side effect of the drug. After years of “doing everything right”, Brühl’s diabetes and weight management were delayed.
Hip arthroplasty made her almost immobile, which led to weight gain and lack of energy. “It seemed like there was nothing I could do to get rid of it,” said lawyer Brühl. “My stomach didn’t know the end of all food in the world.”
Worried Brühl, who was diagnosed with fatty liver disease in June 2019, began skipping breakfast except coffee to reduce calories and lose some weight.
Starting tilzepatide that September, she began to lose 5-10 pounds a month. By July 1, 2020, she had lost nearly £ 60 and gave one of the best results so far from her medicine.
The more Brulee lost, the better she felt and she was able to resume weekend hikes and other physical activities. This helped her feel better.
The medicine prevented her from eating too much, Bruhl said. If she is too spoiled, her food will come back. She said, “She learned to quit before she felt that way.”
Bruehl no longer needs metformin for diabetes and fatty liver has disappeared. One of the negative side effects was nausea. This is what Brühl felt the day after he was injected with tyrzepatide every week. She said an anti-nausea pill that morning processed it.
The biggest challenge for Bruehl was to adapt to how people treat her differently after weight loss. “I went to counseling about body image and solved some of the problems I had,” she said, accepting what she was looking in the mirror and reacting with anger to comments about her new things. He added that it took time to stop doing it. “It took me a while to get used to my skin again.”
Bruehl started dating after being single for many years and now has a long-term partner.
“I feel more balanced. I feel like I’m myself now,” she said. “This trial has regained my life for me.”
Exam details
A new tyrzepatide trial called SURMOUNT-1 meets the medical definition of obesity and has a body mass index of 30 or higher, or a slightly lower BMI but at least one weight-related health problem in 2,500 people. The above volunteers were included.
The average BMI of the participants was 38, 70% were Caucasian and about the same number were female. Almost everyone taking the drug saw improvements in blood sugar, blood pressure, and lipid levels. The trial began in December 2019 and was completed despite the ongoing pandemic of COVID-19.
Dr. Ania Justrebov, an obesity medicine expert at Yale University who helped lead the trial, said her patients responded to tyrzepatide in different ways, partly in total benefit, just like any other drug. Was not obtained. However, 9 out of 10 lost weight, averaging 52 pounds each at the highest dose of 15 mg.
Drugs like semaglutide and current tilzepatide “make it possible to actually take care of patients in the way they need to take care of them,” Justrebov said. “They effectively readjust the biology and help people recover their weight.”
Justrebov said reducing certain foods or eating less overall could help most patients through the side effects of new weight loss medications. She said of these medicines, “Eating beyond fullness” and “feeling like having three Thanksgiving suppers.”
Justrebov said he often has to help patients through the self-blame they feel by carrying extra weight. She sees obesity not as an individual’s fault, but as a fight against the biological urge to retain extra weight. “These drugs safely and effectively target their physiology,” she said.
She said patients need to continue weight-reducing medications, as well as medications to treat other chronic illnesses such as diabetes, high cholesterol, and high blood pressure. If they maintain a lower weight for a period of time, they may be able to continue at lower doses or be completely reduced, but it needs to be studied, she said.
One obstacle for many is the price of weight loss medications.
It’s too early to know the price Lily will set for Tirzepatide. Mounjaro, the same drug used to treat diabetes at the same dose, A little less than $ 1,000 a month..
Semaglutide has been in short supply since it hit the market last year to lose weight, Lind said. The cost of a 2.4 mg weight loss dose is about $ 1,600 a month, which is higher than the 1 or 2 mg dose used to treat diabetes. Like other weight loss drugs, semaglutide is not covered by many insurance plans.
“Access and cost – that’s what we work on every day as a provider,” says Jastreboff.
Bruehl recently launched a low dose of semaglutide to treat diabetes and the onset of weight loss. Insurance covers everything except about $ 30 a month.
She’s okay with the fact that you probably need to take it forever to lose weight, just as the genetic risk of diabetes probably means you need to treat it forever. She said exercise and a careful diet also need to be part of her ongoing regimen.
“This requires a lifetime of dedication.”
Please contact Karen Weintraub ([email protected]).
Health and patient safety coverage at USA TODAY is partially made possible by grants from the Masimo Foundation for ethics, innovation and competition in health care. The Masimo Foundation does not provide editorial input.
|
Sources 2/ https://www.usatoday.com/story/news/health/2022/06/04/diabetes-drug-could-game-changer-obesity-new-study-shows/7490446001/ The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
