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Charity Launches £ 80m Program with U.S. Partners to Address Cancer Challenges

Charity Launches £ 80m Program with U.S. Partners to Address Cancer Challenges

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The world’s largest cancer research charity and the region’s largest government funder hopes to revive post-pandemic medical research and tackle the greatest challenges posed by the disease, with a new £ 295 million. We have started a partnership.

Cancer Research UK and the US Government’s National Cancer Institute have invested £ 80m in four international projects as part of the Cancer Grand Challenges initiative. This initiative has at least two funding rounds.

For £ 20m each, the winning team will work on: Mysterious muscle wasting caused by cancer; an abnormal ring of DNA that helps tumor evolution. And the stage of tumor development.

Thursday’s announcement was a sign of new investment in Covid-19’s post-pandemic medical research, reducing charity income and disrupting the working life of scientists.

” [Covid] The pandemic has caused considerable damage to cancer clinical research and delayed our basic science work by 6-12 months, “said Charles Swanton, CRUK’s Chief Clinician. “The Grand Challenge is a perfect example of how we can regain our initiative by addressing what I consider to be the four biggest problems in cancer medicine.”

3D images representing data collected on tumor growth

3D images representing data collected on tumor growth © Cancer Research UK

Michelle Mitchell, CEO of CRUK, said: “Our ambitions here are enormous and we can expect to see incredibly exciting discoveries from these teams in the coming years.”

CRUK predicts that the pandemic will reduce revenues by £ 200m over a three-year period and reduce the three-year budget for front-line research by £ 150m. Charities have pledged to provide sustainable levels of research funding totaling £ 1.5 billion over the next five years.

The CancerCachexiaAction Network, a large group of researchers in the United States and the United Kingdom, addresses the debilitating muscle wasting and associated weakness that plagues many people with advanced cancer. Cachexia results from a complex and poorly understood interaction between the tumor and the patient’s metabolism, and there is no effective treatment for it.

Researchers investigate an interesting hypothesis that tumors “adjust” this metabolic imbalance to promote their own growth while the entire patient is starving for nutrients.

The Cancer Genetics project investigates “extrachromosomal DNA” or ecDNA, a small ring of genetic material that resides outside the chromosome that contains most of the human genome.

Paul Michel of Stanford University, leader of the ecDNA team, said:

Another challenge is to develop new treatments for solid tumors in children with little improvement in survival over the last 30 years, as opposed to hematological cancers. In particular, the team wants to adapt an innovative immunotherapy called Car-T to pediatric patients.

Other charitable funders have made less contributions to the program. Founded by New York-based and Pamplona Capital Management Chairman Alex Knaster, the Mark Foundation for Cancer Research will donate £ 10m to the agenda for childhood cancer.

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