Obesity is associated with improved long-term survival after nephrectomy

According to a meta-analysis presented at the 2023 AUA Annual Meeting, patients with renal cell carcinoma (RCC) and high body mass index (BMI) undergoing radical nephrectomy compared with those with low BMI. improved overall survival outcomes.¹

“Further study of the underlying biological and physiological mechanisms will allow us to go beyond mere associations and better understand the impact of BMI on post-nephrectomy outcomes,” said Edmund Chiong. , MD, PhD said.

Explaining the background to the study, presenting author Edmund Chiong, MD, PhD, National University of Singapore, said: Paradox. ‘We sought to assess the impact of his BMI on oncological and surgical outcomes in a nephrectomized patient. “

Researchers collected patient data from four electronic databases. They targeted studies addressing oncological and surgical outcomes after nephrectomy. Study screening and data extraction were performed by two independent authors. Any discrepancies were resolved by third party independent authors. Overall, the analysis included data from his 21 studies.

Researchers defined obesity as having a BMI greater than 25.

The oncological outcome results showed that higher BMI predicted better overall survival, with patients with a BMI >25 having a 30% lower risk of death compared with those with a BMI <25. (HR, 0.70; 95% CI, 0.58–0.85). The hazard ratio for overall survival was 0.97 (95% CI, 0.64 to 1.46) between patients with a BMI of 25 to 30 and those with a BMI of <25.

With respect to cancer-specific survival, patients with a BMI >25 had a 40% lower risk of dying from kidney cancer compared with those with a BMI <25 (HR, 0.60; 95% CI, 0.50- 0.73). Patients with a BMI between 25 and 30 had a 40% reduced risk of dying from kidney cancer compared with those with a BMI <25 (95% CI, 0.37 to 0.97) and those with a BMI >30 had a 35% risk Decreased. Mortality from renal cancer versus patients with BMI <25 (HR, 0.65; 95% CI, 0.52-0.82).

Also, with respect to recurrence-free survival, patients with a BMI >25 had a 28% lower risk of recurrence compared with those with a BMI <25 (HR, 0.72; 95% CI, 0.63-0.82), Twenty-five of the 30 patients had a 45% lower risk of recurrence compared with those with a BMI <25 (HR, 0.55; 95%, CI 0.42-0.73).

Commenting on the results of the surgery, Mr. Chiong said: Lower BMI was also associated with better hospital stay, intraoperative or postoperative complications, need for blood transfusion, and conversion to laparotomy, although the differences were not statistically significant. “

In his closing remarks, Mr. Chiong said: Further investigation of the underlying biological and physiological mechanisms will allow us to go beyond mere associations and better understand the impact of BMI on post-nephrectomy outcomes. “

reference

1. Ong C, Law T, Mok A, et al. Impact of body mass index (BMI) on oncological and surgical outcomes in patients undergoing nephrectomy: a systematic review and meta-analysis. Announcement Location: 2023 AUA Annual Meeting. April 28-May 1, 2023. Chicago, Illinois. Abstract MP47-14. Doi: 10.1097/JU.0000000000003293.14

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos