Health
Common artificial sweeteners can cause DNA damage and cancer
- New research shows that sucralose-6-acetate, a chemical found in Splenda, is “genotoxic” and causes DNA damage.
- The results of this study show that sucralose-6-acetate is detrimental to gut health and can cause oxidative stress, inflammation and even cancer.
- When choosing a sugar substitute, stevia or monk fruit may be considered healthier options.
While many people are turning to artificial sugar substitutes to reduce their caloric intake, a growing body of evidence points to potential health hazards associated with these substances.
Now, a new study finds that sucralose-6-acetate, a chemical found in sucralose (sold under the brand name Splenda), causes DNA damage.
Researchers at North Carolina State University and the University of North Carolina at Chapel Hill determined that the chemical was “genotoxic,” meaning it adversely affected the genetic information in cells. They also exposed human intestinal tissue to sucralose to examine its effects on gut health and potential carcinogenicity.
The result was recently Journal of Toxicology and Environmental Health.
Susan ShiffmanCorresponding author of the study and adjunct professor in the Joint Department of Biomedical Engineering at North Carolina State University and the University of North Carolina at Chapel Hill, said: medical news today:
“The most compelling finding is that sucralose contaminants and metabolites can damage the DNA of human blood cells, allowing them to express genes in the human intestinal epithelium that can lead to inflammation and even cancer. It was about having sex.”
For this study, researchers exposed human blood cells to sucralose-6-acetate in several in vitro experiments. The results showed signs of genotoxicity.
Researchers also found that sucralose was to blame. leaky gut Or damage to the intestinal lining. Furthermore, they observed gene activity in enterocytes and found that sucralose caused an increase in enterocyte gene activity. oxidative stressinflammatory, carcinogenic.
The results support growing evidence for the harmful effects of artificial sweeteners, including:
“For many years, artificial sweeteners have been suspected of being carcinogenic.” Dr. Daniel LeonardA board-certified specialist in internal medicine and medical oncology in Calabarzon, Philippines, who was not involved in the study, said: MNT.
“this [study] This is a further step towards confirmation of this hypothesis. The foundational research for this theory has already been established, and I believe preliminary data already exist,” Dr Leonard added.
Although this result is cause for concern, it is unclear what effects sucralose may have on health on a broader scale. Therefore, further research into the effects of sucrose-6-acetate, especially in human trials, is still needed.
“They are still a long way from discovering their applicability to human patients, as they are limited by the fact that they are only in vitro (test tubes) and animal studies,” Dr. Leonardo explained.
Doctor.John Damianossaid a hospital resident at Yale University School of Medicine who was not involved in the study. MNT “The paper studied sucralose-6-acetate alone.”
“Although this compound is an intermediate between sucralose (containing up to 0.67% sucralose) and its metabolites, it does not account for the majority of ingested sucralose, and it is unknown how much is produced in the human gut.” he pointed out.
“The results of this study raise potentially concerning findings that merit further study,” Damianos said. does not really reflect the
Dr. Shiffman said the next step in the research will be to examine the biological effects of sucralose when combined with acesulfame K, another artificial sweetener often included with sucralose in foods.
Future sucralose research may also include population-based studies, which may improve scientists’ understanding of the relationship between sucralose-6-acetate and cancer.
“In the future, population-based studies on the carcinogenic risk of sucralose-6-acetate may be considered. It would be difficult to establish a direct causal relationship, but the data suggest that the public may become more cautious about consuming these artificial sweeteners and move to other “safer” alternatives. already suggested. “
– Dr. Danielle Leonard, Board Certified Specialist in Internal Medicine and Oncology
If you’re wondering if it’s better to consume small amounts of refined sugar instead of excessive amounts of artificial sugar, it may come down to intake in the end.
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Still, health experts warn that 10 teaspoons of sugar a day may still be too much. For example, the American Heart Association (AHA) states:
“We know that excess refined sugar is associated with myriad adverse health effects,” Dr. Damianos said. “There is also accumulating data that certain artificial sweeteners may also be harmful.”
For overall health, experts recommend adhering to a healthy eating pattern that emphasizes whole foods and limits processed and sugary foods.
Dr Damianos said a balanced diet was “consistently associated with better health outcomes.”
Experts recommend avoiding added sugars as much as possible, including natural sugars such as honey and agave.
When choosing a sugar substitute, you can choose: stevia or monk fruit However, we recommend that you consult your doctor first, especially if you have a health condition such as diabetes.
“Natural sugar substitutes that are not lab-made are considered healthier alternatives,” says Dr. Leonardo.
Damianos said he encourages patients to consider healthier low-sugar or sugar-free alternatives given the risks of refined sugar.
“Instead of soda or diet soda, switch to seltzer water,” recommended Dr. Damianos.
“Excluding that highly processed foods Sip a drink to satisfy your sweet tooth and consume fruits that combine natural sugars with a wealth of health-promoting fiber and phytonutrients,” he added.
“Date sugar and yacon syrup are unique sugar substitutes that have a lower glycemic index than sugar, provide health benefits, and help make great bread. Coconut sugar, molasses, honey, maple syrup, and agave are commonly used. However, it should be used sparingly as it can raise blood sugar levels, and I advise my patients to pay particular attention to increasing fiber and healthy fats, which blunt insulin spikes. We recommend that you consider your entire diet.”
– Dr. John Damianos, Yale University School of Medicine
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Sources 2/ https://www.medicalnewstoday.com/articles/sucralose-found-in-common-sweetener-damages-dna-may-cause-cancer The mention sources can contact us to remove/changing this article |
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