Health
Antidepressants and dementia risk: reassuring data
Top line:
Antidepressants are not associated with increased risk of dementia, accelerated cognitive decline, or white and gray matter atrophy in adults without signs of cognitive impairment, a new study suggests.
methodology:
- Researchers studied 5,511 people (58% women, mean age 71 years) in the Rotterdam Study, an ongoing prospective population-based cohort study.
- Participants had no dementia at baseline and were monitored for dementia onset from baseline to 2018 using repeated cognitive assessments using the Mini-Mental State Examination (MMSE), Geriatric Mental Schedule, and MRI. .
- Information on participants' antidepressant use was extracted from pharmacy records from 1992 to baseline (2002–2008).
- During an average follow-up of 10 years, 12% of participants developed dementia.
remove:
- Overall, 17% of participants had used antidepressants in the approximately 10 years prior to baseline, and 4.1% were also using antidepressants at baseline.
- Baseline drug use was more common among women than men (21% vs. 18%), and use increased with age. From 2.1% of participants aged 45-50 he increased to 4.5% of participants aged 80 and older.
- After adjusting for confounders, no association was found between antidepressant use and dementia risk (hazard ratio) [HR]1.14; 95% CI, 0.92-1.41), accelerated cognitive decline, or white and gray matter atrophy.
- However, use of tricyclic antidepressants was associated with increased risk of dementia (HR, 1.12; 95% CI, 0.81 to 1.54) compared with use of selective serotonin reuptake inhibitors (HR, 1.12; 95% CI, 0.81 to 1.54). HR, 1.36; 95% CI, 1.01-1.83).
in fact:
“Prescribing antidepressants to older adults, especially those with some degree of cognitive impairment, can cause acute symptomatic anticholinergic effects that merit consideration in clinical practice, but our results suggest that antidepressant “This study shows that long-term use of 200% does not have lasting effects on cognition or brain health, which is more common in older adults with no signs of cognitive impairment,” the authors wrote.
sauce:
Frank J. Walters, MD, of the Radiology, Nuclear Medicine and Alzheimer Center, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands, is the study's senior author. Published online on April 1st Alzheimer's disease and dementia.
Limitations:
As a limitation, excluding participants with an MMSE <26 at baseline prevented reversal of causality (i.e., antidepressant use in response to depression during the prodromal stage of dementia). However, concerns were included that selection bias may have been introduced by ignoring the effect of antidepressant use during the prodromal stage of dementia. Target the baseline and exclude participants with lower education.
Disclosure:
This study was carried out as part of the Dutch Dementia Cohort Consortium, which receives funding from ZonMW Memorabel and Alzheimer Nederland in association with Delta Plan Dementia. Further funding was also obtained from Stichting Erasmus Trustfonds. This research was further supported by his 2020 NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation. The authors report no conflicts of interest or relevant financial relationships.
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Sources 2/ https://www.medscape.com/viewarticle/antidepressants-and-dementia-risk-reassuring-data-2024a100088s The mention sources can contact us to remove/changing this article |
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