Health

People with rare longevity mutations may also be protected from cardiovascular disease

New research highlights possible cardiovascular health benefits in individuals with a rare disease known as growth hormone receptor deficiency (GHRD), also known as Laron syndrome.

GHRD is characterized by an impairment of the body's ability to use its own growth hormone, leading to stunted growth, and has been associated with a record 40% increase in longevity in mice and a reduced risk of various age-related diseases. It is said that However, the risk of cardiovascular disease in GHRD patients remains unclear, leading to speculation that this mouse longevity mutation may actually increase cardiovascular disease in humans.

Research appearing in and The plan, which will take place on April 26, 2024, was developed by Valter Longo, a professor of gerontology at the Leonard Davis School of Gerontology at the University of Southern California, and endocrinologist Jaime Guevara-Aguirre from the University of San Francisco de Quito in Ecuador. This is the latest result of nearly 20 years of international collaborative research with Mr.

For the past 20 years, Longo, Guevara-Aguirre and colleagues have investigated the health and aging of people with the genetic mutation that causes GHRD. The rare mutation, found in only 400 to 500 people worldwide, was identified in a group of Ecuadorians whose ancestors fled Spain during the Inquisition more than three centuries ago. This mutation disables growth hormone receptors and causes a type of dwarfism.

The research team's previous studies have shown that while GHRD/Laron syndrome suppresses growth, it also appears to reduce the risk of several age-related diseases. Although Ecuadorians with GHRD have high rates of obesity, their risk of cancer and type 2 diabetes is very low. They also seem to have healthier brains and perform better on cognitive and memory tests.

For the current study, the research team examined cardiovascular function, damage, and risk factors in GHRD subjects and their relatives. The researchers conducted a two-stage measurement in Los Angeles and Ecuador in a total of 51 people, 24 with a diagnosis of GHRD and 27 with relatives without GHRD as controls.

Key findings from the study include:

GHRD subjects showed lower blood sugar levels, insulin resistance, and blood pressure compared to controls.
They also had smaller heart dimensions and similar pulse wave velocities (a measure of artery stiffness), but lower carotid artery thickness compared to control subjects.
Despite having elevated low-density lipoprotein (LDL), or “bad cholesterol,” levels, GHRD subjects showed a tendency to have lower carotid atherosclerotic plaque compared to controls (7% vs. 36%).

“These findings suggest that patients with GHRD have normal or improved levels of cardiovascular disease risk factors compared to their relatives,” said Longo, senior author of the new study. Ta. “Although the tested population is small, this human data, together with studies in mice and other organisms, provides valuable insight into the health effects of growth hormone receptor deficiency and suggests that drugs that can cause similar effects This suggests that dietary interventions may reduce the incidence of disease and extend lifespan.” ”

Co-authors of the study include co-corresponding authors Longo and Guevara-Aguirre, as well as Amrendra Mishra and Guevara-Aguirre. Priya Balasubramanian of USC; Carolina Guevara, Alvaro Villales, Gabriela Peña, Daniela Lescano. Alexandra Guevara from the Institute of Endocrinology, Metabolism and Reproduction (IEMYR) in Quito. Marco Canepa of the University of Genoa, Italy. and John Kopchick of Ohio University. Funding has been awarded to his Longo, including National Institutes of Health/National Institute on Aging grant P01 AG034906.

Sources

1/ https://Google.com/

2/ https://www.sciencedaily.com/releases/2024/04/240426164953.htm

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