Health
Breast cancer drug found to be effective against alcohol poisoning, COVID-19
Key Point
- Protease Mpro plays an important role in SARS-CoV-2 replication
- Researchers have discovered that drugs used to treat alcoholism effectively block this protein
- This slows or completely blocks regeneration in the body.
Disulfiram, a drug used to treat alcoholism, and neratinib, an drug for breast cancer, were found to be effective against the new coronavirus, and a new study was reported.
Researchers High School of Economics (HSE) University, Moscow, and Zelinsky Institute of Organic Chemistry discovered this using molecular modeling, and the results were Mendeleev Communication journal.
Like many viruses, coronaviruses tend to mutate rapidly. The ideal target for potential treatment is a structural element of the pathogen that is less susceptible to mutation during its evolution. Otherwise, a valid drug candidate for one strain will not work for another. In these terms, the best candidates are conserved proteins such as the major protease Mpro of the SARS-CoV-2 virus.
Apart from being resistant to mutations, the protease Mpro plays an important role in coronavirus replication. This means that their inhibition can slow down or even stop playback in the body.
The researchers used molecular docking to confirm that disulfiram and neratinib were effective against SARS-CoV-2.
Disulfiram is the most commonly used drug for the treatment of chronic alcoholism. Flushing, headaches, vomiting, nausea, chest pain, weakness, blurred vision, confusion, sweating, anxiety, dyspnea, and even the very small amounts of alcohol can have unpleasant effects. The drug fights the new coronavirus in two ways:
- This drug is a covalent inhibitor, as demonstrated in vitro with MERS and SARS coronaviruses
- Combat COVID-19 symptoms such as reduced glutathione levels because antioxidant deficiency can lead to serious symptoms of the disease
Russian researchers first predicted the efficacy of the breast cancer drug neratinib, an irreversible tyrosine kinase inhibitor against the new coronavirus. In 2017, the US Food and Drug Administration approved the drug as an adjuvant treatment for breast cancer.
Molecular modeling has shown that both of these drugs inhibit the major coronavirus protease Mpro. Experts from Reaction Biology Corp., an accredited laboratory in the US, have demonstrated that disulfiram inhibits Mpro at concentrations of 100 nm, supporting the results of these Russian scientists.
“This finding demonstrates the importance of further development of virtual screening add-ons.
..
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
Pictures Credit
to request, modification Contact us at Here or [email protected]
 |
 |
 |
