Health
To better understand this issue, researchers studied 9,804 children (mean baseline age 9.9 years 、男性53％、白人76％）のデータを分析した。幼少期中期から青年期。
P P -6 P P P -7).
P -6
著者らは、皮質の総厚は1.7歳でピークに達し、生涯を通じて着実に減少することに注目した。 In contrast, subcortical volume peaks at age 14.4 and generally remains stable until a rapid decline later in life.
The authors suggest that the results for nicotine and cannabis may not have had sufficient statistical power, and that the small effects suggest that these results are not clinically beneficial to individuals. He pointed out that there was. However, they write, “they certainly inform and challenge current theoretical models of addiction.”
“The possibility that local associations, such as a thinner cortical thickness in the right rostral middle frontal gyrus, may precede the onset of drug use suggests that these associations are primarily the result of neurotoxicity from exposure. “This question challenges the dominant interpretation that these characteristics are caused by cancer and increases the plausibility that these characteristics may, at least in part, reflect “markers of predispositional risk,” the authors write.
A limitation of the study was that unmeasured confounders or undetected systematic differences in missing data may have influenced the association. Sociodemographic, environmental, and genetic variables not included as covariates are likely to be associated with both neuroanatomical variation and substance use initiation, moderating the association between them.する可能性があると著者らは述べている。
The ABCD study will provide a “robust, large-scale database of longitudinal data” that goes beyond previous neuroimaging studies to “understand the bidirectional relationship between brain structure and substance use,” Miller said.プレスリリースで述べた。
“This type of research, when done in conjunction with other data on environmental exposures and genetic risks, will change the way we think about the development of substance use disorders and provide more accurate models of addiction in the future.期待されています」とミラー氏は述べた。
in , Felix Pichardo, M.A., and Cilia Wilson, Ph.D., of the Child Development Institute at the University of Minnesota, Twin Cities (Minneapolis), say it is time to re-evaluate the causal assumptions and mechanisms that underlie brain disease models of addiction.ているのかもしれないと示唆した。それは発生し、持続し、有害になります。
Editorial committee members praised the ABCD study's large sample size, which provides precision, statistical accuracy, and the ability to identify both large and small effects, which are important for addiction research.
Unlike most addiction studies, which rely on cross-sectional designs, this study used a longitudinal assessment, which the researchers noted was another strength of the study.
“Longitudinal research designs, such as the ABCD study, are the basis for establishing temporal ordering across constructs. Establishing temporal ordering is critical for determining causal relationships and underlying mechanisms.”なステップであるため、これは重要です。」
By including components that provide several genetic information, such as family study designs, nested twin subsamples, and DNA collections, “researchers can move beyond temporal priorities and make causal inferences and mechanisticの特定を強化することが可能になる」と研究者らは付け加えた。
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Sources 2/ https://www.medscape.com/viewarticle/brain-changes-youth-who-use-substances-cause-or-effect-2025a100002e The mention sources can contact us to remove/changing this article |
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