The role of the gut microbiome in fighting infections: research reveals how diet influences risk

New research shows that the ingredients intestinal microbiota This helps predict a person's likelihood of dying from potentially life-threatening infections caused by Klebsiella pneumoniae, E. coli, and other bacteria, and can be changed by changing diet. (Also read: You are what you eat: study reveals surprising link between dietary fiber, gut health and cancer )

group of bacteria Bacteria called the Enterobacteriaceae family, which includes Klebsiella pneumoniae, M. rubella, and E. coli, exist at low levels as part of the gut microbiome of healthy humans. However, certain catalytic factors increase, such as: inflammation These bugs can cause illness and disease by entering the body or by eating contaminated food. In extreme cases, having too many enteric bacteria in your intestines can be life-threatening.

How the gut microbiome is protected from harmful bacteria

Researchers analyzed the composition of the gut microbiome from stool samples from more than 12,000 people in 45 countries using a computational approach that included AI. They found that the “signatures” of a person's microbiome can predict whether a person's gut is likely to be colonized by Enterobacteriaceae. The results are consistent across different health conditions and geographic locations.

Researchers identified 135 gut microbial species that are commonly found even in the absence of Enterobacteriaceae. It will probably protect you from infections. The results will be published in the journal Nature Microbiology. Notable among the species that protect the gut is a group of bacteria called Faecalibacterium, which produce beneficial compounds called short-chain fatty acids by breaking down fiber in the foods we eat.

The role of fiber in promoting gut health

This appears to protect against infection by various disease-causing Enterobacteriaceae bugs. Researchers suggest that consuming more fiber in your diet can support the growth of good bacteria and eliminate bad bacteria, significantly reducing your risk of disease. In contrast, probiotic intake, which does not directly alter the intestinal environment, is less likely to affect the likelihood of Enterobacteriaceae infections.

Dr Alexandre Almeida said: 'Our findings suggest that what we eat is potentially very important in controlling the likelihood of infection by a variety of bacteria, including E. coli and Klebsiella pneumoniae. “This changes the intestinal environment, making it more hostile to invaders.” , a researcher at the University of Cambridge's School of Veterinary Medicine and lead author of the paper.

She added: “Eating fiber from foods such as vegetables, beans, and whole grains can provide the raw materials for your gut bacteria to produce short-chain fatty acids. , a compound that can protect us from these pathogenic insects,” he added. Klebsiella pneumonia can cause pneumonia, meningitis, and other infections.

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