Health
Data suggest that Paxlovid does not reduce severe symbiotic bids in older vaccinated adults
Yesterday's research Jama Paxlovid, an oral antiviral approved for use against severe Covid-19 symptoms, suggests that it rarely reduced the risk of hospitalization and death in older Canadian vaccinated adults Masu.
Pfizer's first clinical trial of drugs was conducted on unvaccinated adults, the authors said the median age between 42 and 46 years old. Elderly people are more likely to be vaccinated against Covid-19 than younger adults, and are at the highest risk of severe complications from the virus.
the study All causes of death and all causes of hospitalization in adults in Ontario, Canada. Between April 1 and November 30, 2022, Ontario implemented an age-based institutional policy regarding access to Paxlovid.
“As the most powerful predictor of severe COVID-19 is advanced age, it was important to obtain evidence as to whether the results of the Pfizer trial were generalized to the elderly and vaccinated populations.” press release From Univy Stie in Los Angeles, California.
The authors compared results in adults under the age of 70 who were not prescribed Paxrovid with those given antiviral properties. The authors identified 1,620,884 Ontarians between 65 and 74 years of age during the study period. Most (87.5%) received at least two Covid-19 vaccines.
Paxlovid is 4 times less effective than clinical trials
Overall, the authors found that the prescription rate for Paxrovids has more than doubled, increasing by 118% at age 70 after the introduction of age-based policies.
However, the increase in the use of Paxlovid did not result in a reduction in hospitalization or deaths among those treated with the medication.
There was no immediate significant difference in Covid-19-related hospitalizations (39.5 vs. 42.9) or all-cause deaths (109.6 vs. 115.7) compared with just over 70 years of age (per 10,000 patients per month). did.
The authors said that in this study, the effect of Paxlovid on Covid-19 hospitalizations in vaccinated elderly people was four times the effect first reported in Pfizer's 2022 clinical trial, with 1.3 percentage points hospitalization He said he would reduce it. The original clinical trial showed an absolute risk reduction of 5.5 percentage points for hospitalization.
“This study found no significant impact on COVID-19 hospitalizations and deaths among vaccinated elderly people, so our findings are the ones that include the crazy elderly and immunosuppressed elderly subgroups. It highlights the urgent need for further randomized clinical trials to investigate the effects of Paxlovid in high-risk populations. “Katherine Kern, Maryland, another study author.
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Sources 2/ https://www.cidrap.umn.edu/covid-19/data-suggest-paxlovid-doesnt-reduce-severe-covid-older-vaccinated-adults The mention sources can contact us to remove/changing this article |
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