Health
Ebselen, a Synthetic Drug for Bipolar Disorder and Hearing Loss, May Help Treat COVID-19: Study
In a new study, Professor Juan De Pablo of the University of Chicago and his colleagues found that Ebselen, a synthetic drug currently being investigated for use in the treatment of deafness and bipolar disorders, directed against SARS-CoV-2. Claims to be valid.
The study was published in an open-access peer-reviewed journal Scientific progressConducted using state-of-the-art computer simulation. So far, there have been no clinical trials demonstrating the effects on coronavirus patients.
This drug has been shown to bind to the coronavirus protease Mpro, which is involved in SARS-CoV-2, COVID-19-causing viral replication, and viral entry into host cells.
Ebselen
Ebselen is an organic selenium compound that has been shown to have anti-inflammatory, antioxidant and cytoprotective effects (protecting healthy cells). Prevents cell damage caused by reactive oxygen species. Ebselen has also been proposed to have neuroprotective (brain cell protection) properties.
The drug has been investigated for its effects on Meniere’s disease, noise-induced hearing loss, tinnitus, and bipolar disorder. It has also been suggested to be effective against multidrug-resistant Staphylococcus aureus. Meniere’s disease is a disease of the inner ear that causes dizziness, hearing loss, and tinnitus. It usually affects one ear and hearing loss can be permanent. Staphylococcus aureus causes a variety of infections, from skin infections such as boiling to severe and life-threatening respiratory tract infections.
Previous clinical studies have shown the drug’s safety in humans. In 2019, the US Food and Drug Administration designated SPI-1005, a drug containing ebselen, as a fast track for the treatment of Meniere’s disease.
Mpro
Previous studies have shown that Mpro is a protease enzyme that is resistant to mutations and is an ideal target site for drugs. Once upon a time, Russian researchers Disulfiram, Drugs used to treat alcoholism can bind to and inactivate Mpro. This helps prevent the virus from making a copy of itself and thus contain the infection.
Ebselen works similarly. You can identify and bind to Mpro’s active site. Enzymes are proteins that fold to make the active site. These sites are like pockets where substrates bind and enzymes function.
Apart from the active site of Mpro, ebselen can also bind to other sites of the enzyme. This changes the structure of the active site so that it cannot bind to the original substrate.
New category of pharmaceuticals
The researchers say the study points to a potential new category of Mpro inhibitors, drugs for the treatment of coronavirus infections.
so news releaseResearchers said the findings were particularly important because they revealed a new vulnerability in the virus that causes COVID-19.
Drugs such as lopinavir and ritonavir, which have been proposed for COVID-19 treatment, also target SARS-CoV-2 proteases such as 3CLpro and PLpro.
The team is still investigating drugs that could affect SARS-CoV-2 and could be used to treat COVID-19. Dr. Pablo announced that he will soon announce information on another drug candidate with potential coronavirus disease.
For more information on the drugs diverted to COVID-19, Scientists are trying these existing drugs to treat COVID-19
The Firstpost Health article was created by myUpchar.com, India’s first and largest resource for validated healthcare information. At myUpchar, researchers and journalists work with doctors to provide all health information.
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