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Antibiotics Associated With Increased Risk of Inflammatory Bowel Disease: Research | Health News

Washington: The team believes that the use of antibiotics that cover a wider range of microbes may be associated with an increased risk of emerging inflammatory bowel disease (IBD) and its subtypes of ulcerative colitis and Crohn’s disease I found that there is a nature.

A study led by researchers at the Karolinska Institute in Sweden and Harvard Medical University in the US was published in The Lancet Gastroenterology and Hepatology. The association between antibiotic treatment and IBD remained when patients were compared to siblings.

IBD has become more common, especially in Europe, the United States, and elsewhere in the world due to rapid economic development, improved hygiene, and more frequent use of antibiotics. With increasing awareness of the role of the gut microbiota in maintaining human health, there is growing concern that antibiotics may disrupt and forever change these fragile microbial communities.

This can potentially affect the risk of gastrointestinal disorders. In the largest study ever linked the risk of antibiotic therapy to IBD, researchers in Sweden and the United States found that more frequent use of antibiotics was associated with IBD and its subtypes, ulcerative colitis and the development of clones. I was able to show more clearly what I am doing. s illness.

“I think this corroborates many of us suspicion-antibiotics that adversely affect the intestinal microbial community are risk factors for IBD,” Long Nguyen of the Massachusetts General Hospital and Harvard Medical School in Boston. Said the doctor. ..

“But despite this compelling rationale and seemingly intuitive guessing, there has been no population-scale study to support this hypothesis so far,” the investigators conclude by epidemiology enhanced by histoPathology Reports in Sweden. Through the study (ESPRESSO), we identified almost 24,000 new IBD cases (16,000 had ulcerative colitis and 8,000 Crohn’s disease), compared them to 28,000 siblings, and compared to 117,000 controls in the general population. Did.

Previous use of antibiotics (until and ever) has been associated with an almost 2-fold increase in risk of IBD, after adjusting for several risk factors. There is an increased risk for both ulcerative colitis and Crohn’s disease, with the highest estimates corresponding to broad spectrum antibiotics.

Previous research in this area is small, with few follow-ups over the years, according to the researchers. In contrast, researchers in this study were able to enroll all consecutive eligible patients with new-onset IBD from a population-based register over the 10-year study period, limiting selection bias.

“In Sweden, there is a universal drug treatment with virtually complete information on all drug preparations, including antibiotics, to minimize confirmation bias,” said Medical Epidemiology at the Oedro University Hospital Pediatrician. Department professor Jonas F Ludvigsson said: And Biostatistics, Karolinska Institute.

“This makes the Swedish registry ideal for studying IBD risk factors.” IBD affects almost 1 percent of the Swedish population and can have a major impact on the lives of patients. This is associated with an increased risk of both death and cancer.

“Our research provides another piece of the puzzle and more reasons to avoid unnecessary use of antibiotics.”

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