Breath test for cancer detects 80% of cases in early trials

The pursuit of low-cost, non-invasive early cancer screening is a common goal among medical researchers, and the Australian team claims significant progress in this area. The team has developed a breath test that can detect the breath profile associated with head and neck cancer. This tool has shown high accuracy in early testing.

Over the past few years, we have seen many promising breath tests for cancer. Many of these techniques work by analyzing volatile organic compounds (VOCs) in the breath. This can manifest itself as a unique pattern when the body’s metabolism is disrupted by the disease.

Efforts to detect and classify these unique breath-based biomarkers have gained some serious momentum in recent years, with promising results from studies involving breath testing. esophagus And Gastric cancer, And we have seen a breath test for lung cancer And even more Generalized approach Move on to clinical trials.

The author of a new study at Flinders University in Australia focuses on head and neck cancer. It accounts for 6% of all cancers and kills about 300,000 people worldwide each year. Treatment is effective if the disease is detected early, but it is often not the case, and late-stage illnesses lead to a poor prognosis.

Flinders University

“Our study identified a unique profile of VOCs that can distinguish head and neck cancer patients from non-cancer patients in the Australian patient cohort,” lead author Dr. Roger Yasbeck told New Atlas. I will.

The cohort consisted of 181 patients with suspected early-stage head and neck cancer who had not yet been treated. Using an ion flow tube mass spectrometer of choice, VOC respiration was analyzed and the team was able to determine specific patterns associated with head and neck cancer.

When testing breath tests, researchers found that there was an 80% chance of accurately detecting cancer and an 86% chance of accurately detecting benign cases. These results were confirmed by tissue biopsy analysis and then in another group of patients.

“The main advantage of our work is that we used an independent group to verify the accuracy of the test,” says Yazbek. “Although the number of patients in this study was relatively small, the fact that the accuracy of the test was maintained in this independent patient group gives us great confidence in the usefulness of the test in clinical applications.”

From here, researchers hope to build on these promising results in larger trials involving more diverse patient groups with different ethnicities, genders, and cancer stages. I will. If it proves to be successful across a larger cohort, it can find a way to clinical use.

“Our grand vision is a handheld device that can be used at the Point of Care to quickly provide doctors with information about suspected head and neck cancer,” says Yazbek.

The study was published in British Journal of Cancer..

Source: Flinders University via MedicalXpress

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