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“Killer” cells in Ebola immunology research may help Covid’s research | World News
Disclaimer from deadly things Ebola The virus can last for years after infection, and the world’s longest study of survivors by British and Guinean scientists concluded with findings that could affect Covid immunology research.
The findings are the result of the world’s longest and most comprehensive study of survivors in the devastating West Africa between 2013 and 2016. These can help you understand your body. Immune response to COVID And other zoonotic diseases.
Recent studies suggest that antibodies to Covid may last only two months, immunity to the virus may not last long, and those who recover are at risk of reinfection.
Team of scientists Guinea Found that some survivors of Ebola did not show antibodies three months after infection, even though they had to respond strongly to fight such a deadly virus. Did.
However, it fights the possibility of reinfection with backup “killer” T cells, a type of white blood cell that triggers an immune response, and B cells, which remember the pathogen’s specific combat plan and rapidly secrete antibodies when reactivated. I had the ability.In the survey results published in Lancet Infectious Disease Journal..
Current post-Covid tests are for antibodies only, not T or B cells.
“Unable to detect antibodies does not necessarily mean that someone has not acquired immunity from the infection,” said the report’s lead author, a professor at Oxford University, a national public health infectious service. Said Miles Carroll, Deputy Director of. England in Porton Down, Wiltshire.
The study is the largest in the world, with scientists taking blood samples from 117 Guinean survivors, 66 contacts, and 23 negative control subjects over a three-year period to “both neutralizing antibody and T cell responses.” Can be evaluated independently.
According to their study, 95% of survivors have both antibody and T cell responses to the virus, and there is a “significant reduction” in either antibody or T cells more than 3 years after infection. I couldn’t see it. These results suggest that naturally acquired immunity is 10-fold higher than the immunity provided by the new Ebola vaccine, which was successfully used in the latest 2018-19. Outbreak In Africa.
“This finding provides compelling evidence of long-term protection against reinfection with the Ebola virus,” the study said.
Scientists also suggest that the entire pathogen needs to be considered when designing a new vaccine, not just the components that decorate the surface of the virus.
Scientists were surprised by the verifiable reports of symptoms in nine of the 66 close contacts of people infected with Ebola, usually the mother, who had both antibodies to the virus and T cells. It was a discovery that there was none.
“These data suggest that more people were actually infected with the virus than official reports suggest,” the newspaper said. This can affect the understanding of herd immunity against other viruses. In the limelight For Covid.
The study also provides some support for the presence of viral infections from asymptomatic individuals after a woman infects her child with the Ebola virus via breast milk with fatal consequences.
Neither of the children’s parents reported symptoms of Ebola, and the blood samples were virus-free. However, their semen and breast milk turned out to be positive, concluding that breast milk was the most likely route of transmission.
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