Health
Coronavirus Vaccine: A human challenge test, or deliberately infecting a patient to speed up the vaccine, raises ethical concerns.
Throughout the United States, coronavirus vaccine trials are growing towards the goal line after returning home after receiving the vaccine or placebo for several months. But what if researchers could speed up the process by deliberately infecting them with a virus? This is known as the Human Challenge Trial.
Dr. Yvonne Maldonado, an infectious disease expert at Stanford University, explained that “it could actually take less time because people don’t have to wait for the infection.”
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And now, British researchers have begun organizing the country’s first human challenge test for COVID-19. At the same time, Congressman Bill Foster of Illinois co-wrote a letter to the Health and Welfare Department and the Food and Drug Administration asking them to consider a challenge trial to speed up vaccine development.
“Scientifically, it’s far more controlled than a large trial of 30,000 people receiving half of the vaccine, half of the dummy vaccine, and waiting for months,” Foster claimed.
An example of an alternative dates back more than a century when a British doctor successfully tested his own rudimentary vaccine against smallpox by deliberately exposing an 8-year-old boy to illness. In addition, some influenza vaccines use limited challenge trials. However, the possibility of getting someone sick with a dangerous virus poses a potential ethical problem for some researchers in the Bay Area because there is no cure.
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“I don’t know how much virus to give to people and whether it’s enough or too much. Whether or not you give it is different from how you get it naturally,” said Dr. Maldonado.
Another Stanford colleague, Dr. Phil Grant, believes that there is an ethical line when dealing with viruses as new as COVID-19.
“For me, even if participants were willing to take on the challenge, it would go beyond what I consider to be a reasonable risk,” Dr. Grant said.
However, supporters argue that new coronavirus treatments, such as the monoclonal antibody drug given to President Donald Trump, are evidence of a changing situation that may make challenging trials safer. And as standard trials are progressing or nearing completion, supporters believe that smaller challenge trials can help scientists focus faster on the most effective vaccines. I will.
“There is a big difference between the 70% effective vaccine and the 90 or 95% effective vaccine,” Foster argued.
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Currently, nothing has been announced about the official move in the United States, but a few weeks ago, Dr. Anthony Fauci said government researchers were working on a weakened version of the COVID-19 virus. I confirmed it to. Fauci described the task as merely preventative, but experts said the weakened version could potentially help if the United States finally decided to proceed with a human challenge test. Is called.
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