Health
Decreased reliability of prescription strength fish oil
More than 13,000 patients treated at centers around the world received placebopills containing epanova or corn oil. All patients were in a “high cardiovascular risk” condition.For example, they were treated in cholesterol-Drop Statins There was an obstruction of the coronary arteries, or arteries of the brain or legs, or there was a risk of heart disease due to the following conditions: Diabetes Lifestyle risk factors like or smoking..
Registration for the trial began in 2014. The trial ended in January 2020, the Lincoff group said.
During that period, more than 1,600 patients experienced some kind of cardiac event. However, the use of Epanova did not reduce deaths from heart disease, heart attack, Stroke, Need Stent Or hospitalized for bypass surgery or angina.
The treatment had at least one drawback.Researchers say the use of prescription strength fish oil appeared to be associated with an increased risk, commonly referred to as arrhythmias. Atrial fibrillation..
But if Epanova doesn’t seem to bring any benefits, why did heart patients get another omega-3 prescription, Vascepa, and apparently get health benefits?
According to Calfman, the answer may be in trial design.
Vascepa contains a form of purified EPA known as icosapentethyl. Clinical trials that seemed to validate the efficacy of Vascepa lasted for five years. Researchers have found that the use of this drug is associated with a 25% reduction in various heart events when compared to placebo — in this case. Mineral oil..
“Why did these two high-quality clinical trials using the same high doses of omega-3 fatty acids come to the opposite conclusion?” Asked Calfman.
The choice of placebo (mineral oil or corn oil) may help explain the contradiction, he said. Perhaps Vascepa “did not reduce the risk of cardiovascular events, but instead the comparator mineral oil increased the risk of cardiovascular events,” Calfman theorized. He reasoned that it might create the illusion that Vascepa helped the patient.
There is some evidence that mineral oil can raise levels LDL “Bad” cholesterol, Calfman pointed out.
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