Health
Researchers find new ways to measure cognitive impairment, dementia
Flail index scores allow clinicians to identify patients at risk. Cognitive impairment, Make it an important marker of prognostic value.
Newly published data suggest that the accumulation of health disorders, especially among older Americans, affects the likelihood of progressive cognitive impairment and the potential for cognitive improvement. APOE ε4 allele.
Lead author David D. Dr. Ward, Postdoctoral Fellow, Geriatrics Research, Geriatrics Center, Novascosia Health Department, and colleagues calculated vulnerability index scores using a deficit-accumulating approach for participants over the age of 50. National Alzheimer’s Coordination Center (NACC).
Among people without cognitive impairment (NCI; n = 9773), each increase in score by 0.1 increased the risk of developing mild cognitive impairment (MCI) and increased the risk of developing dementia. ..
In total, 14,490 participants with an average age of 72.2 participated in this study. The baseline MCI subsample (n = 4717) is less likely to be reclassified as NCI from MCI and the degree of vulnerability associated with a higher risk of returning to MCI for those reclassified as NCI. Was expensive. There is an increased risk of developing dementia.
“We find that frailty is a major risk factor for age-related cognitive impairment and dementia, and occurs between people with MCI and the target of interventions aimed at preventing age-related cognitive impairment. We conclude that it represents both of the prognostic markers, “the author writes.
Scores are a measure of health that incorporates information from multiple physiological systems and closely reflect an individual’s risk to adverse health events and mortality, regardless of age in chronological order. Higher flail index scores showed an accumulation of more age-related health problems while estimating biological age.
The researchers sought to elaborate on the dynamic nature of cognitive function by calculating the potential for transitions between bidirectional cognitive states over a 12-month period. Decreased cognitive function was considered a forward transition, while improved cognitive function was defined as a reverse transition.
Researchers also have a flail index score APOE The state of the ε4 allele carrier had an independent or interactive effect on the cognitive state transition probability.
They did not find any statistically significant interactions between these variables for NCI subsample transitions. However, in the MCI subsample, the association between flail index score and risk of developing dementia is APOE Ε4 alleles (risk of interaction) than non-carriers [HR], 0.88; 95% CI, 0.80 to 0.97).
There was no meaningful difference in these associations when non-white participants were removed from the analysis sample. In particular, there was no significant difference between males and females in the association between flail index scores and transition probabilities.
Over 12 months, NCI subsample participants maintained their previous status 43,086 times (90.6%) and transitioned between states 4491 (9.4%), of which 3086 (68.7%) were transitions between cognitive states. Yes, 1405 (31.3%) went dead. Of the cognitive state transitions in the NCI subsample, 80.9% were forward transitions and 19.1% were reverse transitions. In the MCI subsample, 70.5% were anterior, compared to 29.5% who experienced a posterior transition.
“This study supports a new conceptualization of late-onset dementia as a complex result of aging, which is often closely related to the general health and genetic risk factors of individuals,” the authors write. wrote.
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