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Africa’s Largest Covid Treatment Clinical Trial Launched by Network of 13 Countries | Global Health
A network of 13 African countries has joined forces with researchers from around the world to launch the largest clinical trial of Covid-19 treatment potential on the African continent.
Anticov’s study, involving the Institute of Tropical Medicine Antwerp and international research institutes, treats mild to moderate cases of Covid-19 early and provides a fragile and already overloaded healthcare system in Africa. The aim is to identify treatments that can be used to prevent a surge in hospitalizations that can be overwhelming. ..
Clinical trials will be led by physicians from African countries and will be conducted in 19 locations in 13 countries. This initiative came after seeking a better response to the coronavirus in developing countries and the challenges of underfunded healthcare systems.
“A large-scale clinical trial of Covid-19 in Africa is needed to answer research questions specific to the African situation,” said Dr. John Nkengason, director of the Centers for Disease Control and Prevention in Africa.
“African countries have responded impressively to Covid-19 so far, and now is the time to prepare for the future wave of the disease. It answers one of our most pressing questions. Helps: In a Limited Intensive Care Facility in Africa-Can We Treat Covid-19 People Faster and Prevent Our Hospitals Overwhelmed? “
The study tested the efficacy of treatment in 2,000 to 3,000 mild to moderate patients in Burkina Faso, Cameroon, Côte d’Ivoire, Democratic Republic of the Congo, Equatorial Guinea, Ethiopia, Ghana, Guinea, Kenya, Mali, Mozambique and Sudan. To do. , And Uganda, the aim is to identify treatments that can prevent the progression of coronavirus to serious disease and limit infection.
Research Adaptive Platform TrialAn innovative type of clinical trial that is a pioneer in anticancer drugs, allowing multiple treatments to be tested at the same time. Adaptive platform trials allow you to make rapid decisions, such as adding, continuing, or stopping treatment groups based on ongoing results analysis.
“The Institute for Tropical Medicine in Antwerp, Belgium has been working closely with our Ethiopian partners for many years,” said Professor Johan Van Griensven of the Institute.
“We can work with more than 10 other African countries to investigate whether early-treated, mildly ill Covid-19 patients are experiencing less serious complications.” He said. “In African countries, few hospitals have sufficient staff and intensive care units, so this strategy is necessary to avoid straining vulnerable healthcare systems.”
As evidence of possible mild to moderate cases becomes apparent, new treatments will be added to the trial.
Initially, Anticov will focus on drugs that can provide the missing efficacy data for mild to moderate patients in large randomized clinical trials. The study will begin testing the control group with the HIV antiretroviral drug combination lopinavir-ritonavir and the malaria drug hydroxychloroquine.
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