Another Massachusetts-based biotechnology company is working on the COVID-19 vaccine with federal support.
By the end of March, Gritstone Oncology, based in Emeryville, Calif., Will begin early-stage clinical trials of a vaccine that will protect people from emerging, more contagious strains of the coronavirus. Approximately 60 of the 170 employees are in Cambridge and use artificial intelligence to determine the optimal target for the virus that the antibody attacks.
With a five-year history of no approved products, Gritstone is backed by the National Institute of Allergy and Infectious Diseases. The agency, led by Dr. Anthony Fauci since 1984, has collaborated with Cambridge-based Moderna on the COVID-19 vaccine, the second vaccine allowed for emergency use against the coronavirus, following the Pfizer-BioNTech vaccine.
Following news of government cooperation, the stock price of a small biotechnology rose more than 248% on Tuesday, closing at $ 22.27.
The company states that it has developed a new vaccine that has cleared the first two vaccines for emergency use, using the characteristic spike protein of the coronavirus. However, Gritstone wants to use other parts of the coronavirus to induce a type of white blood cell called a T cell to attack the pathogen.
“The approach is to point more guns at different parts of the virus and attack them in multiple places,” said Dr. Andrew Allen, co-founder and CEO of Gritstone. .. The goal is to protect people from multiple variants of the coronavirus, including the first surfaced and more contagious strains in the United Kingdom and South Africa.
NIAID supports funding early-stage clinical trials through the Infectious Diseases Clinical Research Consortium, a network that conducts such studies.
The Bill & Melinda Gates Foundation is funding the project, but Allen didn’t say anything.
The vaccine should be given twice. The first is to cause the body to produce coronavirus proteins that stimulate the immune response, relying on adenovirus, which can usually cause the common cold. This is similar to the vaccine developed by Johnson & Johnson and Beth Israel Dikones Medical Center. The second shot relies on messenger RNA, similar to the vaccine developed by Pfizer-BioNTech and Moderna.
Jonathan Salzmann can be reached at [email protected]..
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