Systems recently constructed to turn on gene activity may improve the treatment of a wide range of neurological disorders. Estevan Engel, a researcher in viral neuroengineering at the Princeton Institute for Neuroscience, and his team have developed a new gene promoter that acts like a switch that turns gene expression on. long period.
The analysis was published online this week in the journal Molecular Therapy: Methods & Clinical Development.
Crew members develop these gene switches and use them in gene therapy, the practice of delivering new genes to replace or support potentially defective genes. Gene therapy is a promising strategy for many diseases, including problems involving the brain such as Parkinson’s disease and Alzheimer’s disease.
To deliver genes to cells, scientists take advantage of the fact that viruses work with machines to gain entry into cells. Over the years, scientists have developed viruses to deliver genes in a safe and disease-free manner.
Engel and his staff have created a new gene promoter that turns the gene on after it has been transported to neurons (cells in the brain and nervous system).
The crew designed the promoter by adopting the attributes of the promoter found in another class of viruses, the herpes virus. The herpes virus persists in the body for years by showing a chronic infection in the nervous system.
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