“Unique infection profile” makes treatment of Covid-19 difficult: Lancet

Increasing the number of cases is a unique infection profile in a review published in the well-known journal The Lancet, as the number of cases of Covid-19 has skyrocketed worldwide, especially in India, and many wonder why it is difficult to treat. It became clear that it was due to.

Reviews have increased evidence that the virus infects both the upper and lower respiratory tracts.

Reviews suggest that it is different from “low pathogenic” humans Coronavirus A variant that usually colonizes the upper respiratory tract and causes cold-like symptoms, or a “highly pathogenic” virus that causes SARS or ARDS that normally colonizes the lower respiratory tract.

In addition, more frequent multi-organ effects, thrombosis, and abnormal immunoinflammatory responses that are not generally associated with other similar viruses have evolved Covid-19’s uniquely challenging set of properties. Means.

“Appearance of Severe Acute Respiratory Syndrome Coronavirus The two that cause Covid-19 (SARS-CoV-2) have caused a health crisis that has not been witnessed since the 1918 Spanish flu pandemic. Tragically, millions have already died worldwide, “said Ignacio Martin-Loeches, co-author, clinical professor at Trinity College Dublin.

Animal and models suggest that an overly aggressive immune-inflammatory response is an important driving force, but things seem to work differently in humans-inflammation is a factor, which is ours. Fight the virus, which is a unique dysregulation of the immune response that causes the body to mismanage those methods.

“Despite the international attention to the virus, we are just beginning to understand its complexity,” said Martin Loeches.

“Based on increasing evidence, we propose that Cvid-19 should be recognized as a new entity with a previously unknown infection profile. It has unique characteristics and distinct pathophysiology. , We need to be aware of this when treating people, “added Martin-Loeches. ..

However, the co-authors also said that it does not mean that existing best practice treatments based on the knowledge of other human coronaviruses need to be abandoned.

However, a fair and step-by-step assembly of major Covid-19 puzzle pieces for different patient cohorts based on gender, age, ethnicity, and existing comorbidities changes existing treatment guidelines and is then most appropriate. It’s what you need to provide something. Care for Covid-19 patients.

–IANS

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