Health
New insights into the action of androgens may help fight prostate cancer-ScienceDaily
Researchers at the UVA Cancer Center have revealed important new insights into how a hormone called androgen acts on cells. This finding may support efforts to develop better treatments for prostate, ovarian, and breast cancer.
This finding reveals how androgens interact with intracellular receptors to affect gene activity. This process is important for both healthy cells and certain cancers. For example, hormone therapy for prostate cancer aims to reduce the amount of androgens in the body or prevent androgens from fueling cancer cells. However, this approach does not work for some men and ultimately fails for others. Therefore, scientists are keen to better understand how our cells (and cancers) interact with androgens.
“Our research reveals a new mechanism for how androgens regulate communication within prostate cancer cells,” said Dr. Bryce M. Pascal of the University of Virginia School of Medicine, Department of Biochemistry and Molecular Genetics. Said. “Antiandrogens continue to be the basis of prostate cancer treatment. The more we understand how androgens work, the more clinicians can understand why they fail and how to design better treatments. Will be. “
Androgens and cancer
In a new treatise in a scientific journal Nature Communications, Paschal and his colleagues explain how complex signaling systems regulate androgen receptor activity. The system they discovered uses “writers” and “readers” to modify cellular proteins. It’s like how a computer reads and writes information.
Scientists recognize the importance of these modified proteins, but it has been difficult to understand how they affect androgen receptors. One key to the regulatory process discovered by Paschal and his SOM team is the enzyme Parp7, which is produced by the PARP7 gene. Parp7 is part of a family of enzymes involved in important cellular functions, including DNA repair.
Certain anti-cancer drugs already target certain Parp enzymes. These drugs are used to treat prostate, ovarian, and breast cancer in patients with mutations in DNA repair genes. Androgens are usually discussed in the context of prostate cancer, but androgens can also be important in ovarian and breast cancer.
Paschal’s new discoveries may provide fresh insights into these Parp medications and lead to improved treatments that help patients get the best results. In addition, Paschal and his team found low levels of Parp7 in prostate cancer that has spread to other parts of the body than the original tumor. It may suggest that a decrease in Parp7 is associated with disease progression, researchers say.
Paschal and his colleagues, with new androgen insights, have provided scientists with important new directions for exploring in the fight against prostate and other cancers.
“Our next step is to use preclinical models to determine the role this pathway plays in the progression of prostate cancer and whether inhibition of the pathway delays the disease,” Paschal said. I will. “We are very excited about what we have learned so far. Our research still has a lot to learn, and basic science is important in defining the molecular background of enzymes and drug action. It emphasizes that it plays a role. “
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material Provided by University of Virginia Health System.. Note: The content can be edited in style and length.
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