Anticoagulants May Help Patients With Severe Covid-19 Infection

The findings of the team at Mount Sinai Hospital complicate a nasty problem that is shocking and frightening to doctors treating coronavirus patients around the world, a disease that is already difficult to treat. May help the whole body clot.

The team says they are currently conducting experiments to see which anticoagulants are most effective and at what doses they work.

“ Patients who received anticoagulants were more effective than those who did not, ” said Dr. Valentin Fuster, director of Mount Sinai Heart and chief physician of Mount Sinai disease, at CNN. Told.

“This already makes sense. I believe people should treat these patients with antithrombotic drugs,” he added.

The findings are not yet clear enough to make a clear recommendation. The team said already severely ill patients are more likely to receive anticoagulants.

Results improved

Fuster and colleagues examined more than 2,700 patients treated in Mount Sinai, New York City, who were hit hard by the coronavirus. Since March, some patients have been given anticoagulants based on bedside judgment by their doctors.

The team began to systematically investigate whether the drug would make a difference. They did so, especially for patients who were ventilated to help them breathe.

They found that 29% of ventilator-fed patients died compared to 63% of ventilator-free patients.

“Our findings suggest that systemic anticoagulants may be associated with improved outcomes in patients admitted with Covid-19.”

The researchers found that patients receiving anticoagulants were significantly more likely to develop one of the drug’s risks, the bleeding problem.

Since different patients received different doses and different types of anticoagulants, it is important to systematically study which combination of dose and drug is most effective, Huster said.

“Coagulation is okay, okay”

His team has begun such studies and will test different doses of either classical blood thinner heparin or new oral anticoagulants such as the direct thrombin inhibitor dabigatran in the future.

Blood coagulation is arguably the leading cause of death in Covid-19 patients, according to Fuster.

“I’ve done 75 autopsies, and my coagulation is fine, and it’s fine,” he said.

“It starts with the lungs, then the kidneys, the heart, and the brain.”

The results were devastating, he said. “It’s very dramatic for all of us. You feel that you can do almost nothing except to sustain the life of the patient,” Huster said.

Fuster also wants to study whether anticoagulants can help patients who are not ill enough to be hospitalized. Some hospitals are reporting problems Increased stroke Among people under the age of 50 who are usually not at risk. Many of these patients were later found to have the coronavirus.

It is not yet clear why the virus causes blood to clot, but increased coagulation can be a side effect of severe inflammation caused by some viral infections.

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