Health
Antidepressants: A study by the New England Journal of Medicine found that even those who are thinking of trying can be very difficult to stop.
A study of British patients with a long history of depression reveals how difficult it is to stop dosing, even for those who feel good enough to try.
More than half of the participants who gradually discontinued antidepressants relapsed within a year. In contrast, those who continued on regular medication during the study had a low recurrence rate of nearly 40%.
Both groups were taking common antidepressants daily and felt healthy enough to recover from a recent depressive attack and consider quitting the drug.
Previous studies have also shown that recurrence is common, and an editorial published in the New England Journal of Medicine study recommends lifelong medication for some patients who have had several previous seizures. It suggests that there is a possibility.
Counseling and behavioral therapy are other options for those who want to stop antidepressants. Studies have shown that combining these treatments with medication can help many people.
In a government-sponsored study, few UK patients received any psychological treatment. The UK’s National Health Service provides it, but it is difficult to access due to the long waiting times for treatment, said Gemma Lewis, a researcher at the University of London and lead author of the study. According to Lewis, the patients in this study were being treated for depression by a general primary care physician in the United Kingdom.
Depression is a mood disorder that includes persistent and debilitating sadness, hopelessness, and loss of interest in normal activities. According to the World Health Organization, it affects about 5% of adults worldwide. Reported rates are slightly lower in the United Kingdom and higher in the United States. But different ways of assessing depression make it difficult to compare countries, Lewis said.
The survey enrolled 478 people in four cities in the United Kingdom, most of them middle-aged white women. All were taking a common class of antidepressants called selective serotonin reuptake inhibitors. This includes drugs known under the brand names Prozac and Zoloft. Half were randomly assigned and the drug was gradually discontinued. Others did not change the drug. It is unclear if similar results will be achieved with other patients taking other antidepressants.
Although 56% of patients who discontinued medication relapsed during the study, Lewis noted that a significant proportion, including most patients taking antidepressants, did not relapse.
“Many people want to continue using antidepressants, and this treatise shows that it’s a good decision for many,” says Lewis.
Dr. Jeffrey Jackson of Milwaukee’s Veterans Medical Center, who wrote the accompanying editorial, said the findings were important but disappointing. However, he also suggested that antidepressant discontinuation is possible for some patients.
“I consider discontinuing antidepressant treatment after at least 6 months of remission in patients with a single depressive attack, especially those with episodes caused by life events such as the loss of a loved one. I encourage you to do that, “Jackson wrote in an editorial.
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