Health
Investigating the relationship between vitamin D and accidental bone fractures
An estimated 53.6 million people in the United States have osteoporosis, low bone mass, or both, and 2 million osteoporotic fractures occur each year. A new study predicts that the number of osteoporotic fractures per year will exceed 3 million by 2040. Associated costs escalate to over $95 billion.
Merrill S. Leboff, M.D., Ph.D., of Brigham and Women’s Hospital and a research team will evaluate vitamin D3, n-3 fatty acids, or a combination of both to determine whether they can prevent cancer and cardiovascular disease. conducted the test. The team specifically focused on men over the age of 50 and women over the age of 55 in the United States.
Vitamin D supplements are often recommended to improve bone health, but researchers say the data are unclear as to whether vitamin D supplements prevent fractures.
vital research
The primary endpoints of the Vitamin D and Omega 3 Trial (VITAL) were accidental total fractures, non-vertebral fractures, and hip fractures. A proportional hazards model was used to estimate treatment effects in intention-to-treat analyses.
Vitamin D supplementation3 It was tested to see if it reduced the risk of fracture compared to placebo. In a 2-to-2 factorial randomized controlled trial, vitamin D supplementation was provided to participants.3 (2000 IU per day), n-3 fatty acids (1 g per day), or both.
Vitamin D deficiency, low bone mass, or osteoporosis were not grounds for recruitment. Participants reported the occurrence of fractures on annual questionnaires, and the reports were adjudicated by a central medical records review.
result
“Among generally healthy middle-aged and older adults who were not selected for vitamin D deficiency, low bone mass, or osteoporosis, vitamin D3 supplementation did not significantly reduce fracture risk over placebo. .
A total of 1991 incident fractures were identified in 1551 participants with a median follow-up of 5.3 years. There was no significant improvement in the effect of vitamin D on total fractures when compared to placebo.
There was no change in treatment effect by baseline characteristics including age, sex, race or ethnic group, BMI, or serum 25-hydroxyvitamin D levels. Between-group differences in adverse events, as assessed in the parent study, were not substantial.
“Findings were similar for secondary endpoints that excluded toe, finger, skull, peri-prosthetic, and pathologic fractures. We also found no effect of vitamin D supplementation.3 compared with placebo for major osteoporotic fractures and other exploratory endpoints including pelvic and wrist fractures.
the study, “Vitamin D supplementation and accidental bone fractures in the middle-aged and elderlywas published in New England Journal of Medicine.
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