Health
Moderna develops mRNA vaccine for Ebola
Moderna may be preparing to test its mRNA vaccine technology against Ebola, a disease far more deadly than COVID-19.
reported by Bloomberg In late October, the Massachusetts-based biotech company was nearing a contract with the Department of Defense to develop mRNA vaccines against “various biological threats” such as Ebola.
Citing sources who have not been authorized to speak about the deal, which has not yet been formally announced, the deal will combine Moderna and researchers at the University of Texas Medical School (UTMB) in Galveston to develop a vaccine.
Previous Moderna researchwas published in 2018 and showed that a modified mRNA vaccine could protect guinea pigs from Ebola virus (although note that guinea pigs are not the gold standard model for the disease).
Moderna is reportedly nearing a contract with the Department of Defense for research, and may be putting its mRNA vaccine platform into testing against Ebola.
Ebola has moved beyond monkeypox and SARS-CoV-2 to the top of the public health conversation as the outbreak in Uganda, which began in late September, continues to spread. As of November 7with 136 confirmed cases and 53 deaths from Ebola, with a fatality rate approaching 40%.
There are several vaccines and antiviral drugs licensed against Ebola, but they are only designed for the Zaire Ebola strain (which caused an outbreak in West Africa in 2014).
Uganda now faces another beast. Ebola virus in Sudanvaccines and drugs against one virus may offer partial protection against related strains, although this unlikely This is the case with the Ebola virus in Sudan.
According to Bloomberg, Moderna’s mRNA vaccine will be designed to combat both the Sudanese and Zaire strains, as well as Ebola’s deadly cousin, Marburg.
Norbert Purdy, a vaccinologist at the University of Pennsylvania, said an mRNA vaccine could have several advantages over current options. Nature.
An ideal vaccine would protect against multiple strains of Ebola.
They use the genetic code to convey instructions to which antigens cells crank out (such as the spike protein in SARS-CoV-2) and alter what mRNAs encode to initiate an immune response. It’s just relatively easy. Plug and play platform.
The ideal vaccine would contain multiple or allmembers of Ebola’s deadly family, FiloviridaeIt causes viral hemorrhagic fever, UTMB virologist Alex Bukreyev told Nature. In areas where stringy viruses emerge, one he shot will be easier to distribute.These areas are often rural, poverty-stricken and sometimes he 2018 North Kivu/Ituri Outbreak — torn apart by armed conflict.
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